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CAS 177839-85-9

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(R)-3-amino-4-(4-methyl-phenyl)-butyric acid-HCl

Description:
(R)-3-amino-4-(4-methyl-phenyl)-butyric acid-HCl, also known as baclofen, is a chemical compound that functions primarily as a muscle relaxant and is often used in the treatment of spasticity. It is a derivative of gamma-aminobutyric acid (GABA) and acts as a GABA_B receptor agonist, which helps to inhibit neurotransmitter release and reduce muscle tone. The hydrochloride salt form enhances its solubility in water, making it suitable for pharmaceutical applications. This compound is characterized by its chiral center, which contributes to its specific biological activity. In terms of physical properties, it is typically a white to off-white crystalline powder. Its molecular structure includes an amino group, a carboxylic acid group, and a phenyl ring with a methyl substituent, which are crucial for its pharmacological effects. Safety and efficacy profiles are well-documented, and it is important to consider potential side effects and contraindications when used therapeutically.
Formula:C11H16ClNO2
InChI:InChI=1/C11H15NO2.ClH/c1-8-2-4-9(5-3-8)6-10(12)7-11(13)14;/h2-5,10H,6-7,12H2,1H3,(H,13,14);1H/t10-;/m1./s1
SMILES:Cc1ccc(cc1)C[C@H](CC(=O)O)N.Cl
Synonyms:
  • D-3-Amino-4-(4-methylphenyl)-butyric acid hydrochloride
  • Benzenebutanoic acid, β-amino-4-methyl-, (betaR)-, hydrochloride (1:1)
  • H-D-β-HoPhe(4-Me)-OH.HCl
  • (R)-3-Amino-4-(4-Methylphenyl)Butanoic Acid Hydrochloride
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