CAS 17791-52-5: (tert-Butoxycarbonyl)-L-histidine

Description: (t-Butoxycarbonyl)-L-histidine, commonly referred to as Boc-L-histidine, is a derivative of the amino acid histidine, characterized by the presence of a tert-butoxycarbonyl (Boc) protecting group. This compound is typically used in peptide synthesis as a protective group for the amino group of histidine, which helps to prevent unwanted reactions during the synthesis process. The Boc group is stable under basic conditions and can be easily removed under acidic conditions, making it a valuable tool in organic synthesis. The structure of Boc-L-histidine includes a side chain imidazole ring, which is essential for the biological activity of histidine, particularly in enzyme catalysis and metal ion coordination. The compound is generally white to off-white in appearance and is soluble in organic solvents such as dichloromethane and dimethyl sulfoxide, but less soluble in water. Its molecular formula reflects the presence of carbon, hydrogen, nitrogen, and oxygen, and it is often utilized in the synthesis of various peptides and pharmaceuticals due to its ability to facilitate the formation of peptide bonds while maintaining the integrity of the histidine residue.

Formula: C₁₁H₁₇N₃O₄

InChI: InChI=1S/C11H17N3O4/c1-11(2,3)18-10(17)14-8(9(15)16)4-7-5-12-6-13-7/h5-6,8H,4H2,1-3H3,(H,12,13)(H,14,17)(H,15,16)/t8-/m0/s1

InChI key: InChIKey=AYMLQYFMYHISQO-QMMMGPOBSA-N

SMILES: O=C(OC(C)(C)C)NC(C(=O)O)CC1=CN=CN1

Synonyms:

• (+)-N^α-(tert-Butoxycarbonyl)-<span class="text-smallcaps">L</span>-histidine
• (2S)-2-[(tert-butoxycarbonyl)amino]-3-(1H-imidazol-5-yl)propanoate
• (2S)-2-[[(tert-Butoxy)carbonyl]amino]-3-(1H-imidazol-4-yl)propanoic acid
• (2S)-3-(1H-Imidazol-3-ium-5-yl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoate
• (tert-Butoxycarbonyl)-<span class="text-smallcaps">L</span>-histidine
• (tert-Butoxycarbonyl)histidine
• <span class="text-smallcaps">L</span>-Histidine, N-[(1,1-dimethylethoxy)carbonyl]-
• Boc-His-OH
• Histidine, N-carboxy-, N-tert-butyl ester
• Histidine, N-carboxy-, N-tert-butyl ester, <span class="text-smallcaps">L</span>-
• N(alpha)-boc-l-histidine
• N-(tert-butoxycarbonyl)-L-histidine
• N-(tert-butoxycarbonyl)histidine
• N-Boc-L-Histidine
• N-[(1,1-Dimethylethoxy)carbonyl]-<span class="text-smallcaps">L</span>-histidine
• N-tert-Butoxycarbonyl-<span class="text-smallcaps">L</span>-histidine
• N-tert-Butyloxycarbonyl-<span class="text-smallcaps">L</span>-histidine
• N-α-Boc-L-histidine
• N^α-(tert-Butyloxycarbonyl)-<span class="text-smallcaps">L</span>-histidine
• NSC 334942
• tert-Butyloxycarbonyl-<span class="text-smallcaps">L</span>-histidine
• Histidine, N-carboxy-, N-tert-butyl ester, L-
• tert-Butyloxycarbonyl-L-histidine
• N-[(1,1-Dimethylethoxy)carbonyl]-L-histidine
• L-Histidine, N-[(1,1-dimethylethoxy)carbonyl]-

Nα-(tert-Butoxycarbonyl)-L-histidine

CAS: 17791-52-5

• Formula: C₁₁H₁₇N₃O₄
• Purity: >98.0%(T)(HPLC)
• Color and Shape: White to Almost white powder to crystal
• Molecular weight: 255.27

Boc-His-OH

CAS: 17791-52-5

Bachem ID: 4000667.

• Formula: C₁₁H₁₇N₃O₄
• Purity: > 99%
• Color and Shape: White
• Molecular weight: 255.27

L-​Histidine, N-​[(1,​1-​dimethylethoxy)​carbonyl]​-

CAS: 17791-52-5

• Formula: C₁₁H₁₇N₃O₄
• Purity: 95%
• Color and Shape: Solid
• Molecular weight: 255.2704

Boc-His-OH

CAS: 17791-52-5

• Formula: C₁₁H₁₇N₃O₄
• Molecular weight: 255.27

Boc-His-OH

CAS: 17791-52-5

• Formula: C₁₁H₁₇N₃O₄
• Purity: 99+%
• Color and Shape: off-white solid
• Molecular weight: 255.27g/mol

Boc-His-OH

CAS: 17791-52-5

M03292 - Boc-His-OH

• Formula: C₁₁H₁₇N₃O₄
• Purity: 98%
• Color and Shape: Solid, Chunks or Crystalline Powder
• Molecular weight: 255.2740020751953

Boc-His-OH

CAS: 17791-52-5

Boc-His-OH is a protected amino acid derivative.N-Boc-L-Histidine is used as an intermediate in peptide synthesis …

• Formula: C₁₁H₁₇N₃O₄
• Purity: 99.93%
• Color and Shape: Solid
• Molecular weight: 255.27

Na-Boc-L-histidine

CAS: 17791-52-5

Applications Nα-Boc-L-histidine is an N-Boc-protected form of L-Histidine (H456010). L-Histidine is an essential amino acid …

• Formula: C₁₁H₁₇N₃O₄
• Color and Shape: Neat
• Molecular weight: 255.27

Boc-L-Histidine

CAS: 17791-52-5

Boc-L-histidine is a histidine derivative with a boronic acid group that can be used to …

• Formula: C₁₁H₁₇N₃O₄
• Purity: Min. 98 Area-%
• Color and Shape: White Powder
• Molecular weight: 255.27 g/mol

BOC-L-Histidine extrapure, 98.5%

CAS: 17791-52-5

• Formula: C₁₁H₁₇N₃O₄
• Purity: min. 98.5%
• Color and Shape: White, Crystalline powder
• Molecular weight: 255.27

Nα-BOC-L-Histidine, 99+%

CAS: 17791-52-5

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. …

• Formula: C₁₁H₁₆N₃O₄
• Purity: 99+%
• Color and Shape: White to off-white, Powder or crystals and/or chunks
• Molecular weight: 254.27