Nociceptin (1-13) amide, also known as nociceptin or orphanin FQ, is a neuropeptide that plays a significant role in pain modulation, stress response, and various physiological processes. It is derived from the precursor protein prepronociceptin and consists of a sequence of 13 amino acids, with an amide group at the C-terminus, which is crucial for its biological activity. This peptide interacts with the nociceptin/orphanin FQ peptide receptor (NOP), which is part of the opioid receptor family but does not produce the typical opioid effects. Nociceptin (1-13) amide is involved in the regulation of pain perception, emotional responses, and neuroendocrine functions. Its characteristics include a relatively short half-life in circulation, making it a subject of interest for research in pain management and potential therapeutic applications. Additionally, due to its unique receptor interactions, nociceptin has been studied for its implications in addiction, anxiety, and other neuropsychiatric disorders.

Nociceptin (1-13) amide

178064-02-3: Nociceptin (1-13) amide, also known as nociceptin or orphanin FQ, is a neuropeptide that plays a significant role in pain modulation, stress response, and various physiological processes. It is derived from the precursor protein prepronociceptin and consists of a sequence of 13 amino acids, with an amide group at the C-terminus, which is crucial for its biological activity. This peptide interacts with the nociceptin/orphanin FQ peptide receptor (NOP), which is part of the opioid receptor family but does not produce the typical opioid effects. Nociceptin (1-13) amide is involved in the regulation of pain perception, emotional responses, and neuroendocrine functions. Its characteristics include a relatively short half-life in circulation, making it a subject of interest for research in pain management and potential therapeutic applications. Additionally, due to its unique receptor interactions, nociceptin has been studied for its implications in addiction, anxiety, and other neuropsychiatric disorders.

<p>Nociceptin (1-13), amide is a potent ORL1 (OP4) receptor agonist with a pEC50 of 7.9 for mouse vas deferens and a Ki of 0.75 nM for binding to rat forebrain</p>

Nociceptin (1-13), amide

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CAS 178064-02-3

Nociceptin (1-13) amide

Nociceptin (1-13), amide

Ref: TM-TP1793

Nociceptin (1-13) amide trifluoroacetate salt

Ref: 3D-FN109170