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CAS 17834-03-6

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7-Hydroxywarfarin

Description:
7-Hydroxywarfarin is a derivative of warfarin, a well-known anticoagulant medication. It is characterized by the presence of a hydroxyl group at the 7-position of the coumarin ring structure, which influences its pharmacological properties. This compound is typically a white to off-white crystalline solid that is soluble in organic solvents and has limited solubility in water. As a metabolite of warfarin, 7-hydroxywarfarin plays a significant role in the drug's metabolism and pharmacokinetics, contributing to its anticoagulant effects. The compound exhibits anticoagulant activity, although it is generally less potent than warfarin itself. Its mechanism of action involves the inhibition of vitamin K epoxide reductase, which is crucial for the synthesis of vitamin K-dependent clotting factors. Additionally, 7-hydroxywarfarin can be used as a biomarker for monitoring warfarin therapy and understanding individual responses to anticoagulation treatment. Safety and toxicity profiles are similar to those of warfarin, necessitating careful monitoring in clinical settings.
Formula:C19H16O5
InChI:InChI=1S/C19H16O5/c1-11(20)9-15(12-5-3-2-4-6-12)17-18(22)14-8-7-13(21)10-16(14)24-19(17)23/h2-8,10,15,21-22H,9H2,1H3
InChI key:InChIKey=SKFYEJMLNMTTJA-UHFFFAOYSA-N
SMILES:C(CC(C)=O)(C1=C(O)C=2C(OC1=O)=CC(O)=CC2)C3=CC=CC=C3
Synonyms:
  • 2,7-dihydroxy-3-(3-oxo-1-phenylbutyl)-4H-chromen-4-one
  • 2H-1-Benzopyran-2-one, 4,7-dihydroxy-3-(3-oxo-1-phenylbutyl)-
  • 3-(Alpha-Acetonylbenzyl)-4,7-Dihydroxycoumarin
  • 3-(Α-Acetonylbenzyl)-4,7-Dihydrocoumarin
  • 3-(α-Acetonylbenzyl)-4,7-dihydrocoumarin, 4-7-Dihydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one
  • 4,7-Dihydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one
  • 4-7-Dihydroxy-3-(3-Oxo-1-Phenylbutyl)-2H-1-Benzopyran-2-One
  • Coumarin, 3-(α-acetonylbenzyl)-4,7-dihydroxy-
  • Triethyloxonium Hexafluorophosphate
  • 7-Hydroxywarfarin
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