CAS 178433-03-9

O-(2-[18F]Fluoroethyl)-L-tyrosine

Description:

O-(2-[18F]Fluoroethyl)-L-tyrosine, commonly referred to as [18F]FET, is a radiolabeled amino acid used primarily in positron emission tomography (PET) imaging, particularly for the assessment of brain tumors. This compound is characterized by the incorporation of the radioactive isotope fluorine-18, which allows for its visualization in vivo. The structure features a tyrosine backbone, which is an essential amino acid, modified with a 2-fluoroethyl group. This modification enhances its uptake in tumor cells, as many tumors exhibit increased amino acid transport activity. [18F]FET is known for its favorable pharmacokinetics, including rapid blood clearance and low background activity in normal brain tissue, making it a valuable tool for differentiating between tumor recurrence and radiation necrosis. Additionally, its synthesis involves the nucleophilic substitution of a suitable precursor with [18F]fluoride, followed by purification and formulation for clinical use. Overall, [18F]FET represents a significant advancement in molecular imaging, aiding in the diagnosis and management of various malignancies.

Formula: C₁₁H₁₄FNO₃

InChI: InChI=1S/C11H14FNO3/c12-5-6-16-9-3-1-8(2-4-9)7-10(13)11(14)15/h1-4,10H,5-7,13H2,(H,14,15)/t10-/m0/s1/i12-1

InChI key: InChIKey=QZZYPHBVOQMBAT-LRAGLOQXSA-N

SMILES: C([C@@H](C(O)=O)N)C1=CC=C(OCC[18F])C=C1

Synonyms:

• O-(2-[18F]Fluoroethyl)-L-tyrosine
• O-(2-Fluoroethyl)-L-tyrosine-18F
• 18F-FET
• O-[2-(Fluoro-18F)ethyl]-L-tyrosine
• L-Tyrosine, O-[2-(fluoro-18F)ethyl]-

Fet F-18

CAS: 178433-03-9

Fet F-18 is an amino acid analog radiolabeled with fluorine F-18, a positron-emitting isotope, can be used as a tracer in positron emission tomography (PET).

Formula: C₁₁H₁₄FNO₃

Color and Shape: Solid

Molecular weight: 226.23

Ref: TM-T31787