As of my last update in October 2023, there is limited publicly available information regarding the chemical substance identified as MCTR2 with the CAS number 1784701-62-7. This compound may be a specialized or proprietary chemical, potentially used in specific industrial applications, research, or as a pharmaceutical agent. Typically, substances like this can exhibit unique characteristics such as specific solubility in solvents, reactivity with other chemicals, and distinct physical properties like melting and boiling points. The safety profile, including toxicity and handling precautions, would also be crucial for users. For detailed characteristics, including molecular structure, applications, and safety data, consulting specialized chemical databases, scientific literature, or safety data sheets (SDS) would be necessary. If MCTR2 is under research or development, further information may emerge as studies progress or as it becomes more widely used in various fields.

Maresin conjugates in tissue regeneration 2 (MCTR2) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid (DHA; ) in macrophages at the site of inflammation. DHA is oxidized to maresin 1 (MaR1; ), which is converted to MCTR1 by glutathione S-transferase Mu 4 or leukotriene C
4
synthase then to MCTR2 by γ-glutamyl transferase. MCTR2 accelerates tissue regeneration in planaria (1 and 100 nM). Pretreatment with MCTR2 prior to
E. coli
administration reduces neutrophil infiltration, shortens the inflammatory resolution period, and increases phagocytosis of
E. coli
by macrophages. When administered at a dose of 100 ng 12h post
E. coli
infection in a mouse model of peritonitis, MCTR2 selectively reduced the amount of the eicosanoids PGD
2
and PGF
2α
in the exudate.

MCTR2

1784701-62-7: As of my last update in October 2023, there is limited publicly available information regarding the chemical substance identified as MCTR2 with the CAS number 1784701-62-7. This compound may be a specialized or proprietary chemical, potentially used in specific industrial applications, research, or as a pharmaceutical agent. Typically, substances like this can exhibit unique characteristics such as specific solubility in solvents, reactivity with other chemicals, and distinct physical properties like melting and boiling points. The safety profile, including toxicity and handling precautions, would also be crucial for users. For detailed characteristics, including molecular structure, applications, and safety data, consulting specialized chemical databases, scientific literature, or safety data sheets (SDS) would be necessary. If MCTR2 is under research or development, further information may emerge as studies progress or as it becomes more widely used in various fields.

MCTR2, synthesized from DHA in macrophages, aids in tissue repair and reduces inflammation by promoting eicosanoid PGD2 and PGF2α decrease.

CAS 1784701-62-7

MCTR2

MCTR2

Ref: TM-T37506