CAS 178603-78-6

interleukin-1B (1L-1B) converting*enzyme (ice) in

Description:

Interleukin-1β converting enzyme (ICE), also known as caspase-1, is a crucial enzyme involved in the inflammatory response and the processing of pro-inflammatory cytokines. It plays a significant role in the activation of interleukin-1β (IL-1β) and interleukin-18 (IL-18), which are key mediators in immune responses. ICE is a cysteine protease that belongs to the caspase family, characterized by its ability to cleave specific peptide bonds in target proteins, leading to their activation or inactivation. The enzyme is typically found in the cytoplasm and is activated in response to various stimuli, including pathogen-associated molecular patterns. Dysregulation of ICE activity has been implicated in several inflammatory diseases, making it a target for therapeutic intervention. The CAS number 178603-78-6 specifically identifies a compound related to ICE, which may be used in research or drug development contexts. Overall, ICE is essential for maintaining immune homeostasis and mediating inflammatory processes.

Formula: C₂₄H₃₃ClN₄O₈

Synonyms:

• Ac-Tyr-Val-Ala-Asp-chloromethylketone
• Ac-Yvad-Cmk

Ac-Tyr-Val-Ala-Asp-chloromethylketone

CAS: 178603-78-6

Cell-permeable, irreversible inhibitor of caspase-1 (ICE). N.Rouquet et al. showed that Ac-YVAD-CMK is a potent therapeutic agent against in vivo liver apoptosis in mice.

Formula: C₂₄H₃₃ClN₄O₈

Purity: 97.9%

Color and Shape: White Lyophilisate

Molecular weight: 541.01

Ref: 01-4018838

Ac-YVAD-CMK

CAS: 178603-78-6

Ac-YVAD-CMK: Irreversible Caspase-1 inhibitor; halts pyroptosis, IL-1β/IL-18; neuroprotective and anti-inflammatory.

Formula: C₂₄H₃₃ClN₄O₈

Purity: 97.08% - 99.909%

Color and Shape: Solid

Molecular weight: 540.99

Ref: TM-T36347

L-Alaninamide, N-acetyl-L-tyrosyl-L-valyl-N-[(1S)-1-(carboxymethyl)-3-chloro-2-oxopropyl]-

CAS: 178603-78-6

Formula: C₂₄H₃₃ClN₄O₈

Purity: 95%

Color and Shape: Solid

Molecular weight: 540.9938

Ref: IN-DA002670

Ac-YVAD-CMK

CAS: 178603-78-6

Ac-YVAD-CMK

Purity: ≥95%

Molecular weight: 540.99g/mol

Ref: 54-BUP00534

Ac-YVAD-CMK

CAS: 178603-78-6

Purity: ≥95%

Molecular weight: 540.199

Ref: 10-F862097

Caspase-1 Inhibitor II

Controlled Product

CAS: 178603-78-6

Applications Caspase-1 Inhibitor II is an inhibitor of caspase-1, caspase-4, and caspase-5.

Formula: C₂₄H₃₃ClN₄O₈

Color and Shape: Neat

Molecular weight: 540.99

Ref: TR-C184908

Ac-Tyr-Val-Lys-Asp-H (aldehyde)

CAS: 178603-78-6

Ac-Tyr-Val-Lys-Asp-H (aldehyde) is a peptide that is used as a research tool in cell biology and pharmacology. Ac-Tyr-Val-Lys-Asp-H (aldehyde) is an inhibitor of the ion channels TRPV1 and TRPA1, which are involved in pain perception. Ac-Tyr-Val-Lys-Asp-H (aldehyde) also binds to the receptor for bradykinin, which is involved in inflammatory reactions. Ac-Tyr-Val-Lys-Asp-H (aldehyde) has been shown to inhibit protein interactions with the receptors for acetylcholine, serotonin, histamine, dopamine, and other neurotransmitters. The CAS number for this compound is 178603–78–6

Formula: C₂₆H₃₉N₅O₈

Purity: Min. 95%

Ref: 3D-IAT-3166-V

Ac-Tyr-Val-Ala-Asp-CH2Cl

CAS: 178603-78-6

Ac-Tyr-Val-Ala-Asp-CH2Cl is a peptide that interacts with the receptor. It is a high purity, research tool that has been shown to inhibit ion channels and ligand binding. Ac-Tyr-Val-Ala-Asp-CH2Cl is an antibody that can be used in Cell Biology for research tools and cell culture.

Formula: C₂₄H₃₃N₄O₈Cl

Purity: Min. 95%

Molecular weight: 540.99 g/mol

Ref: 3D-ICL-3180-V

Ac-Tyr-Val-Ala-Asp-chloromethylketone

CAS: 178603-78-6

Ac-Tyr-Val-Ala-Asp-chloromethylketone is a small molecule that activates caspase 1 by cleaving the proenzyme to form the active enzyme. It also inhibits the mitochondrial membrane potential and induces apoptosis in cancer cells. Ac-Tyr-Val-Ala-Asp-chloromethylketone binds to the cytosolic Ca2+ channel and causes neuronal death. The compound has been shown to be effective against myocardial infarction, but not against balloon injury or fetal bovine serum induced apoptosis.

Formula: C₂₄H₃₃ClN₄O₈

Purity: Min. 95%

Molecular weight: 540.99 g/mol

Ref: 3D-FA111035