CAS 178676-65-8

(E)-(3,4-Dihydro-7-methoxy-1(2H)-naphthalenylidene)acetonitrile

Controlled Product

CAS: 178676-65-8

Applications (E)-(3,4-Dihydro-7-methoxy-1(2H)-naphthalenylidene)acetonitrile is an intermediate used in the synthesis of (E)-N-[2-(3,4-Dihydro-7-methoxy-1(2H)-naphthalenylidene)ethyl]acetamide(Agomelatine Impurity) (D450485), which is an impurity of Agomelatine (A430000) which is a melatoninergic agonist and selective antagonist of 5-HT2C receptors and used in the treatment of major depressive disorder. Agomelatine Impurity 2
References Yous, S., et al.: J. Med. Chem., 35, 1484 (1992), Zhdanova, I., et al.: J. Clin. Endocrinol. Metab., 86, 4727 (2001), Cajochen, C., et al.: J. Pineal Res., 35, 149 (2003),

Formula: C₁₃H₁₃NO

Color and Shape: Neat

Molecular weight: 199.25

Ref: TR-D450481