CAS 178925-43-4

Cytidine, N-benzoyl-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-5-bromo-2′-deoxy-, 3′-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

Description:

Cytidine, N-benzoyl-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-5-bromo-2′-deoxy-, 3′-[2-cyanoethyl bis(1-methylethyl)phosphoramidite] is a complex chemical compound primarily used in the field of nucleic acid chemistry, particularly in the synthesis of oligonucleotides. This substance features a cytidine base, which is a nucleoside composed of a pyrimidine ring and a ribose sugar, modified with a benzoyl group and a phosphoramidite moiety that facilitates its incorporation into DNA strands during synthesis. The presence of bromine and methoxyphenyl groups enhances its reactivity and solubility, making it suitable for various biochemical applications. The phosphoramidite functionality allows for the formation of phosphodiester bonds, essential for building DNA sequences. Additionally, the compound's structure suggests potential for specific interactions with biological targets, which may be explored in therapeutic contexts. Overall, this compound exemplifies the intricate design often employed in synthetic nucleic acids, combining structural modifications that enhance functionality and reactivity.

Formula: C₄₆H₅₁BrN₅O₈P

InChI: InChI=1S/C46H51BrN5O8P/c1-31(2)52(32(3)4)61(58-27-13-26-48)60-40-28-42(51-29-39(47)43(50-45(51)54)49-44(53)33-14-9-7-10-15-33)59-41(40)30-57-46(34-16-11-8-12-17-34,35-18-22-37(55-5)23-19-35)36-20-24-38(56-6)25-21-36/h7-12,14-25,29,31-32,40-42H,13,27-28,30H2,1-6H3,(H,49,50,53,54)/t40-,41+,42+,61?/m0/s1

InChI key: InChIKey=MEFJNSFIFSEDNU-RYHMCHCNSA-N

SMILES: C(OC[C@@H]1[C@@H](OP(N(C(C)C)C(C)C)OCCC#N)C[C@@H](O1)N2C(=O)N=C(NC(=O)C3=CC=CC=C3)C(Br)=C2)(C4=CC=C(OC)C=C4)(C5=CC=C(OC)C=C5)C6=CC=CC=C6

Synonyms:

• Cytidine, N-benzoyl-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-5-bromo-2′-deoxy-, 3′-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

Cytidine, N-benzoyl-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-5-bromo-2′-deoxy-, 3′-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

CAS: 178925-43-4

Formula: C₄₆H₅₁BrN₅O₈P

Molecular weight: 912.8036

Ref: IN-DA0026HU

N4-Benzoyl-5-bromo-2'-deoxy-5'-O-DMT-cytidine 3'-CE phosphoramidite

CAS: 178925-43-4

N4-Benzoyl-5-bromo-2'-deoxy-5'-O-DMT-cytidine 3'-CE phosphoramidite is a novel modified cytosine derivative. It has anticancer activity and can be used in the treatment of cancer cells that are resistant to other anticancer drugs. This product has a high purity and quality, which allows it to be widely used in the synthesis of DNA, RNA, and ribonucleosides. In addition, N4-Benzoyl-5-bromo-2'-deoxy-5'-O-DMT-cytidine 3'-CE phosphoramidite is an activator for diphosphate formation as well as a nucleotide analogue with antiviral effects. This product is also an inhibitor of DNA polymerase α and β, which are enzymes involved in DNA replication.

Formula: C₄₆H₅₁BrN₅O₈P

Purity: Min. 95%

Molecular weight: 912.8 g/mol

Ref: 3D-PB08666