CAS 179007-60-4

N-tert-Butylpiperidine-2-carboxamide

CAS: 179007-60-4

N-tert-Butylpiperidine-2-carboxamide is a small molecule that has been shown to bind to the cavity of the active site of human thiopurine S-methyltransferase (TPMT), blocking access by substrates and competitive inhibitors. It was synthesized as a peptidomimetic inhibitor for TPMT, which is an enzyme that catalyzes the methylation of thiopurines, such as 6-MP. The X-ray crystallographic studies revealed that N-tert-butylpiperidine-2-carboxamide is a homodimeric molecule with two binding sites on each monomer. The inhibition of TPMT by N-tert-butylpiperidine-2-carboxamide results in increased levels of 6MP and decreased levels of 6TG, leading to improved therapeutic outcomes when given with 6MP.

Formula: C₁₀H₂₀N₂O

Purity: Min. 95%

Molecular weight: 184.28 g/mol

Ref: 3D-EHA00760