CAS 179237-49-1

CGP52421

Description:

CGP52421, with the CAS number 179237-49-1, is a chemical compound that functions primarily as a selective inhibitor of the enzyme phosphodiesterase 9A (PDE9A). This enzyme plays a crucial role in the regulation of intracellular levels of cyclic guanosine monophosphate (cGMP), which is involved in various physiological processes, including neuronal signaling and cardiovascular function. CGP52421 is characterized by its ability to enhance cGMP signaling, making it of interest in research related to neurodegenerative diseases and cognitive disorders. The compound is typically studied in the context of its pharmacological effects, potential therapeutic applications, and its role in modulating cGMP pathways. As a synthetic compound, CGP52421 is often evaluated for its efficacy, safety, and pharmacokinetic properties in preclinical and clinical studies. Its specificity for PDE9A distinguishes it from other phosphodiesterase inhibitors, which may target multiple isoforms, thereby potentially reducing side effects associated with broader inhibition.

3-Hydroxy Midostaurin-d5 (CGP52421-d5) (Mixture of Diastereomers)

CAS: 179237-49-1

Formula: C₃₅H₂₅D₅N₄O₅

Color and Shape: Off-White Solid

Molecular weight: 591.68

Ref: 4Z-M-160005

3-Hydroxy Midostaurin

CAS: 179237-49-1

3-Hydroxy Midostaurin (CGP 52421), a PKC412 metabolite, inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50 values of roughly 132 nM in

Formula: C₃₅H₃₀N₄O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 586.648

Ref: TM-T12610L

3-Hydroxy Midostaurin (CGP52421) (Mixture of Diastereomers)

CAS: 179237-49-1

Formula: C₃₅H₃₀N₄O₅

Color and Shape: Pale Yellow Solid

Molecular weight: 586.65

Ref: 4Z-M-160002

CGP52421

CAS: 179237-49-1

CGP52421

Purity: 98%

Molecular weight: 586.65g/mol

Ref: 54-OR1063621

3-Hydroxy Midostaurin

Controlled Product

CAS: 179237-49-1

Stability Hygroscopic
Applications 3-Hydroxy Midostaurin is a metabolite of Midostaurin (M343760), a compound shown to possess antiproliferative characteristics via inhibition of protein kinase C, kinase insert domain receptor, and c-kit.
References Tahtouh, T., et al.: J. Med. Chem., 55, 9312 (2012); Pedeboscq, S., et al.: PLoS. One., 7, 36811 (2012);

Formula: C₃₅H₃₀N₄O₅

Color and Shape: Neat

Molecular weight: 586.64

Ref: TR-H939985

3-Hydroxy Midostaurin-13C6

Controlled Product

CAS: 179237-49-1

Stability Hygroscopic
Applications 3-Hydroxy Midostaurin-13C6 is the labelled analogue of 3-Hydroxy Midostaurin (H939985), a metabolite of Midostaurin (M343760), a compound shown to possess antiproliferative characteristics via inhibition of protein kinase C, kinase insert domain receptor, and c-kit.
References Tahtouh, T., et al.: J. Med. Chem., 55, 9312 (2012); Pedeboscq, S., et al.: PLoS. One., 7, 36811 (2012);

Formula: C₂₉₁₃C₆H₃₀N₄O₅

Color and Shape: Neat

Molecular weight: 592.59

Ref: TR-H939987

3-Hydroxy Midostaurin

CAS: 179237-49-1

Formula: C₃₅H₃₀N₄O₅

Molecular weight: 586.6

Ref: ST-EA-CP-M107006