CAS 179463-17-3

Cancidas

Description:

Cancidas, with the CAS number 179463-17-3, is the brand name for the antifungal agent caspofungin. It belongs to the echinocandin class of antifungals, which are known for their mechanism of action that inhibits the synthesis of β-(1,3)-D-glucan, an essential component of the fungal cell wall. This disruption leads to cell lysis and death of the fungus. Caspofungin is primarily used to treat invasive fungal infections, particularly those caused by Candida and Aspergillus species, especially in immunocompromised patients. It is administered intravenously and is characterized by its relatively low toxicity profile compared to other antifungal agents. The drug is generally well-tolerated, with side effects that may include fever, rash, and gastrointestinal disturbances. Its pharmacokinetics involve a slow elimination half-life, allowing for once-daily dosing. Overall, Cancidas represents a critical option in the management of serious fungal infections, particularly in patients who are resistant to other antifungal therapies.

Formula: C₅₆H₉₆N₁₀O₁₉

InChI: InChI=1/C52H88N10O15.2C2H4O2/c1-5-28(2)24-29(3)12-10-8-6-7-9-11-13-39(69)56-34-26-38(68)46(55-22-21-54)60-50(75)43-37(67)19-23-61(43)52(77)41(36(66)18-20-53)58-49(74)42(45(71)44(70)31-14-16-32(64)17-15-31)59-48(73)35-25-33(65)27-62(35)51(76)40(30(4)63)57-47(34)72;2*1-2(3)4/h14-17,28-30,33-38,40-46,55,63-68,70-71H,5-13,18-27,53-54H2,1-4H3,(H,56,69)(H,57,72)(H,58,74)(H,59,73)(H,60,75);2*1H3,(H,3,4)/t28?,29?,30-,33-,34-,35+,36-,37+,38-,40+,41+,42+,43?,44+,45+,46+;;/m1../s1

Synonyms:

• Caspofungin acetate
• (3S,6S,9S,11R,15S,18S,20R,21S,24S,25S)-21-(2-Aminoethylamino)-3-[3-amino-1(R)-hydroxypropyl]-6-[1(S),2(S)-dihydroxy-2-(4-hydroxyphenyl)ethyl]-18-(10,12-dimethyltetradecanamido)-11,20,25-trihydroxy-15-[1(R)-hydroxyethyl]-1,4,7,13,16,22-hexaazatricyclo[22.3.0.0(9,13)]heptacosane-2,5,8,14,17,23-hexaone diacetate
• N-{(2R,6S,9S,11R,12S,14aS,15S,20S,23S,25aS)-12-[(2-aminoethyl)amino]-20-[(1R)-3-amino-1-hydroxypropyl]-23-[(1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-2,11,15-trihydroxy-6-[(1R)-1-hydroxyethyl]-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl}-10,12-dimethyltetradecanamide
• N-{(2R,6S,9S,11R,12R,14aS,15S,20S,23S,25aS)-12-[(2-aminoethyl)amino]-20-[(1S)-3-amino-1-hydroxypropyl]-23-[(1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-2,11,15-trihydroxy-6-[(1R)-1-hydroxyethyl]-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl}-10,12-dimethyltetradecanamide acetate (1:2)
• N-{(2R,6S,9R,11R,12S,15S,20S,23S,25aS)-12-[(2-aminoethyl)amino]-20-[(1R)-3-amino-1-hydroxypropyl]-23-[(1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-2,11,15-trihydroxy-6-[(1R)-1-hydroxyethyl]-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl}-10,12-dimethyltetradecanamide acetate (1:2)
• Cancidas (Caspofungin Acetate)

Pneumocandin B0, 1-[(4R,5S)-5-[(2-aminoethyl)amino]-N2-[(10R,12S)-10,12-dimethyl-1-oxotetradecyl]-4-hydroxy-L-ornithine]-5-[(3R)-3-hydroxy-L-ornithine]-, acetate (1:2)

CAS: 179463-17-3

Formula: C₅₄H₉₂N₁₀O₁₇

Purity: 98%

Color and Shape: Solid

Molecular weight: 1153.3651

Ref: IN-DA002711

Caspofungin Diacetate

CAS: 179463-17-3

Formula: C₅₂H₈₈N₁₀O₁₅·2C₂H₄O₂

Color and Shape: White To Off-White Solid

Molecular weight: 1093.34 2*60.05

Ref: 4Z-PC-155001

Caspofungin Acetate

CAS: 179463-17-3

Caspofungin Acetate

Purity: ≥95%

Molecular weight: 1213.42g/mol

Ref: 54-BUP06070

Caspofungin acetate

CAS: 179463-17-3

Formula: C₅₂H₈₈N₁₀O₁₅·2C₂H₄O₂

Purity: (HPLC) ≥ 97.0% (anhydrous basis)

Color and Shape: White to off-white powder

Molecular weight: 1213.42

Ref: 7W-GP8659

Caspofungin Acetate

CAS: 179463-17-3

Caspofungin Acetate (MK 0991) is the acetate salt of an antimycotic echinocandin lipopeptide, semisynthetically derived from a fermentation product of the

Formula: C₅₆H₉₆N₁₀O₁₉

Purity: 97.94% - 99.9%

Color and Shape: White Powder

Molecular weight: 1213.42

Ref: TM-T1799

Caspofungin Acetate

CAS: 179463-17-3

Applications An echinocandin that inhibits the synthesis of β (1,3)-D-glucan, an integral component of the fungal cell wall. An antifungal drug used in the treatment of invasive fungal infections.
References Sandhu, P. et al.: Antimicrob. Agents Chemorther., 48, 1272 (2004); Bertsche, T. et al.: Pharamaz. Zeit., 148, 34 (2003); Hoang, A.: Am. J. Health-Sys. Pharm., 58, 1206 (2001);

Formula: C₅₂H₈₈N₁₀O₁₅·2C₂H₄O₂

Purity: >90%

Color and Shape: White To Light Yellow

Molecular weight: 1213.42

Ref: TR-C184900

Caspofungin acetate

Controlled Product

CAS: 179463-17-3

Inhibitor of glucan synthase; antifungal compound

Formula: C₅₂H₈₈N₁₀O₁₅·2C₂H₄O₂

Purity: Min. 90 Area-%

Color and Shape: Powder

Molecular weight: 1,213.42 g/mol

Ref: 3D-FC16269

Caspofungin acetate - Bio-X ™

Controlled Product

CAS: 179463-17-3

Caspofungin is an echinocandin that belongs to the class of antifungal agents. It is used to treat Aspergillus and Candida infections. It works by inhibiting the synthesis of beta-(1,3)-D-glucan, an essential component of the cell wall of Aspergillus species and Candida species.

Formula: C₅₂H₈₈N₁₀O₁₅·2C₂H₄O₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 1,213.42 g/mol

Ref: 3D-BC164293