CAS 179558-91-9

N-[9-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-O-[(1,1-dimethylethyl)dimethylsilyl]-β-D-ribofuranosyl]-9H-purin-2-yl]butanamide

Description:

N-[9-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-O-[(1,1-dimethylethyl)dimethylsilyl]-β-D-ribofuranosyl]-9H-purin-2-yl]butanamide, with CAS number 179558-91-9, is a complex organic compound characterized by its intricate molecular structure, which includes multiple functional groups such as amines, phosphines, and silyl ethers. This compound features a purine base linked to a ribofuranosyl sugar, indicative of its potential biological activity, possibly as a nucleoside analog. The presence of bulky substituents, such as bis(4-methoxyphenyl) and dimethylsilyl groups, suggests that it may exhibit unique solubility and stability properties, which could influence its pharmacokinetics and bioavailability. Additionally, the incorporation of a cyanoethoxy group and a butanamide moiety may enhance its interaction with biological targets, making it a candidate for further investigation in medicinal chemistry. Overall, its structural complexity and diverse functional groups position it as a potentially valuable compound in pharmaceutical research.

Formula: C₅₀H₆₈N₇O₈PSi

InChI: InChI=1S/C50H68N7O8PSi/c1-13-18-43(58)54-48-52-31-41-46(55-48)56(33-53-41)47-45(65-67(11,12)49(6,7)8)44(64-66(62-30-17-29-51)57(34(2)3)35(4)5)42(63-47)32-61-50(36-19-15-14-16-20-36,37-21-25-39(59-9)26-22-37)38-23-27-40(60-10)28-24-38/h14-16,19-28,31,33-35,42,44-45,47H,13,17-18,30,32H2,1-12H3,(H,52,54,55,58)/t42-,44-,45-,47-,66?/m1/s1

InChI key: InChIKey=XJRKARXGQAQMRG-KAZSGHHBSA-N

SMILES: C(OC[C@@H]1[C@@H](OP(N(C(C)C)C(C)C)OCCC#N)[C@@H](O[Si](C(C)(C)C)(C)C)[C@@H](O1)N2C=3C(N=C2)=CN=C(NC(CCC)=O)N3)(C4=CC=C(OC)C=C4)(C5=CC=C(OC)C=C5)C6=CC=CC=C6

Synonyms:

• N-[9-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-O-[(1,1-dimethylethyl)dimethylsilyl]-β-D-ribofuranosyl]-9H-purin-2-yl]butanamide
• Butanamide, N-[9-[5-O-[bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-O-[(1,1-dimethylethyl)dimethylsilyl]-β-D-ribofuranosyl]-9H-purin-2-yl]-

2-Isobutyrylamino-9-(2''-O-tert-butyldimethylsilyl-5''-O-DMT-b-D-ribofuranosyl)purine 3''-CE phosphoramidite

CAS: 179558-91-9

Ref: 7W-GN5687

2-Isobutyrylamino-9-(2'-O-tert-butyldimethylsilyl-5'-O-DMT-b-D-ribofuranosyl)purine 3'-CE phosphoramidite

CAS: 179558-91-9

2-Isobutyrylamino-9-(2'-O-tert-butyldimethylsilyl-5'-O-DMT-b-D-ribofuranosyl)purine 3'-CE phosphoramidite is a modified nucleoside that is used to synthesize DNA. It has antiviral and anticancer properties, which are due to its ability to inhibit viral DNA polymerases and tumor cell proliferation. 2-Isobutyrylamino-9-(2'-O-tert-butyldimethylsilyl-5'-O-DMT-b-D -ribofuranosyl)purine 3'-CE phosphoramidite is also able to interfere with the synthesis of cellular DNA because it can be incorporated into the growing strand at any position. This novel nucleoside can be used in both monophosphate and diphosphate forms. 2 Isobuty

Formula: C₅₀H₆₈N₇O₈PSi

Purity: Min. 95%

Molecular weight: 954.2 g/mol

Ref: 3D-PI09082