CAS 1797406-72-4

L-Prolinamide, N-[14-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]-1,13-dioxo-3,6,9-trioxa-12-azatetradec-1-yl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4S)-

Description:

L-Prolinamide, N-[14-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]-1,13-dioxo-3,6,9-trioxa-12-azatetradec-1-yl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4S)- is a complex organic compound characterized by its intricate molecular structure, which includes multiple functional groups such as amides, dioxo, and hydroxy groups. The presence of a thieno-triazolo-diazepine core suggests potential biological activity, possibly as a pharmaceutical agent. The compound features chiral centers, indicating stereoisomerism, which can influence its biological interactions and pharmacokinetics. Additionally, the presence of aromatic rings, including a chlorophenyl and a thiazolyl moiety, may enhance its lipophilicity and binding affinity to biological targets. The CAS number 1797406-72-4 uniquely identifies this substance in chemical databases, facilitating its study in research and development contexts. Overall, this compound's structural complexity and functional diversity suggest potential applications in medicinal chemistry and drug design.

Formula: C₄₉H₆₀ClN₉O₈S₂

InChI: InChI=1S/C49H60ClN9O8S2/c1-28-30(3)69-48-41(28)42(33-12-14-35(50)15-13-33)54-37(45-57-56-31(4)59(45)48)23-39(61)51-16-17-65-18-19-66-20-21-67-26-40(62)55-44(49(5,6)7)47(64)58-25-36(60)22-38(58)46(63)52-24-32-8-10-34(11-9-32)43-29(2)53-27-68-43/h8-15,27,36-38,44,60H,16-26H2,1-7H3,(H,51,61)(H,52,63)(H,55,62)/t36-,37-,38-,44+/m0/s1

InChI key: InChIKey=PTAMRJLIOCHJMQ-HADAFJFFSA-N

SMILES: CC=1C2=C(N3C([C@H](CC(NCCOCCOCCOCC(N[C@H](C(=O)N4[C@H](C(NCC5=CC=C(C=C5)C6=C(C)N=CS6)=O)C[C@H](O)C4)C(C)(C)C)=O)=O)N=C2C7=CC=C(Cl)C=C7)=NN=C3C)SC1C

Synonyms:

• L-Prolinamide, N-[14-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]-1,13-dioxo-3,6,9-trioxa-12-azatetradec-1-yl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4S)-

cis-MZ 1

CAS: 1797406-72-4

Formula: C₄₉H₆₀ClN₉O₈S₂

Molecular weight: 1002.6392

Ref: IN-DA01ENJI

cis MZ 1

CAS: 1797406-72-4

cis MZ 1 is a negative control for MZ 1 (1797406-69-9) and exhibits no binding affinity for VHL. MZ 1 is a PROTAC degrader targeting BRD4.

Formula: C₄₉H₆₀ClN₉O₈S₂

Purity: 99.23%

Color and Shape: Solid

Molecular weight: 1002.64

Ref: TM-T41200