CAS 1797406-81-5

E3 ligase Ligand-Linker Conjugates 4

Description:

E3 ligase Ligand-Linker Conjugates 4, identified by the CAS number 1797406-81-5, is a chemical compound designed for use in targeted protein degradation applications, particularly in the field of drug discovery and development. This compound typically features a ligand that selectively binds to an E3 ubiquitin ligase, facilitating the ubiquitination and subsequent degradation of specific target proteins within the cell. The linker component is crucial as it connects the ligand to the target protein, ensuring effective proximity and interaction. These conjugates are part of a broader class of molecules known as PROTACs (proteolysis-targeting chimeras), which harness the cell's ubiquitin-proteasome system to eliminate unwanted proteins. The characteristics of such compounds often include high specificity, the ability to modulate protein levels, and potential therapeutic applications in various diseases, including cancer. The design and optimization of these conjugates are critical for enhancing their efficacy and minimizing off-target effects, making them a significant focus in contemporary medicinal chemistry research.

Formula: C₃₂H₄₇N₇O₈S

Synonyms:

• E3 ligase Ligand-Linker Conjugates 4
• VH032-PEG4-N3
• VHL Ligand-Linker Conjugates 5

E3 ligase Ligand-Linker Conjugates 4

CAS: 1797406-81-5

Formula: C₃₂H₄₇N₇O₈S

Purity: 97%

Molecular weight: 689.8227

Ref: IN-DA01EO9O

(S,R,S)-AHPC-PEG4-N3

CAS: 1797406-81-5

(S,R,S)-AHPC-PEG4-N3

Purity: 98%

Molecular weight: 689.82g/mol

Ref: 54-OR1022978

(S,R,S)-AHPC-PEG4-N3

CAS: 1797406-81-5

(S,R,S)-AHPC-PEG4-N3

Purity: ≥98%

Molecular weight: 689.83g/mol

Ref: 54-BUP02054

(S,R,S)-AHPC-PEG4-N3

CAS: 1797406-81-5

(S,R,S)-AHPC-PEG4-N3 (VHL Ligand-Linker Conjugates 5) is a synthesized conjugate that functions as a ligand-linker in E3 ligase-based systems.

Formula: C₃₂H₄₇N₇O₈S

Purity: 98.06%

Color and Shape: Solid

Molecular weight: 689.83

Ref: TM-T17921

(S,R,S)-AHPC-PEG4-N3

CAS: 1797406-81-5

Purity: 97%

Molecular weight: 689.83

Ref: 10-F987744

(S,R,S)-AHPC-PEG4-Azide

CAS: 1797406-81-5

(S,R,S)-AHPC-PEG4-Azide is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. (S,R,S)-AHPC-PEG4-Azide is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

Formula: C₃₂H₄₇N₇O₈S

Purity: Min. 95%

Molecular weight: 689.82 g/mol

Ref: 3D-XWC40681