5-(1-Propylnyl)-2'-O-methyluridine is a modified nucleoside that features a propyne group at the 5-position of the uridine base and a methoxy group at the 2'-position of the ribose sugar. This compound is characterized by its unique structural modifications, which can influence its biological activity and stability compared to unmodified nucleosides. The presence of the propyne group may enhance its ability to participate in various chemical reactions, potentially making it useful in synthetic applications or as a building block in nucleic acid chemistry. The 2'-O-methyl modification is known to confer resistance to enzymatic degradation, which can improve the pharmacokinetic properties of nucleoside analogs. This compound may be of interest in research related to antiviral therapies, RNA interference, or other areas of molecular biology where modified nucleosides play a crucial role. Its specific interactions and efficacy would depend on the context of its use, including the target biological systems and the presence of other molecular components.

5-(1-PROPYNYL)-2'-O-METHYLURIDINE

179817-95-9: 5-(1-Propylnyl)-2'-O-methyluridine is a modified nucleoside that features a propyne group at the 5-position of the uridine base and a methoxy group at the 2'-position of the ribose sugar. This compound is characterized by its unique structural modifications, which can influence its biological activity and stability compared to unmodified nucleosides. The presence of the propyne group may enhance its ability to participate in various chemical reactions, potentially making it useful in synthetic applications or as a building block in nucleic acid chemistry. The 2'-O-methyl modification is known to confer resistance to enzymatic degradation, which can improve the pharmacokinetic properties of nucleoside analogs. This compound may be of interest in research related to antiviral therapies, RNA interference, or other areas of molecular biology where modified nucleosides play a crucial role. Its specific interactions and efficacy would depend on the context of its use, including the target biological systems and the presence of other molecular components.

Uridine, 2'-O-methyl-5-(1-propynyl)- (9CI)

<p>2'-O-Methyl-5-propynyluridine is a nucleoside that is selective to bacterial DNA. It has been shown to inhibit the binding of RNA polymerase and DNA gyrase, as well as the synthesis of RNA and DNA. This nucleoside also inhibits the formation of triplexes in vitro with oligonucleotides complementary to sequences in the 16S ribosomal RNA gene. 2'-O-Methyl-5-propynyluridine has been used for the measurement of RNA polymerase activity in bacteria, and its affinity for triplexes can be measured by gel shift assay.</p>

CAS 179817-95-9

5-(1-PROPYNYL)-2'-O-METHYLURIDINE

Uridine, 2'-O-methyl-5-(1-propynyl)- (9CI)

Ref: IN-DA0027AA

2'-O-Methyl-5-propynyluridine

Ref: 3D-NM06235