5-(1-Propynyl)-2'-O-methylcytidine is a modified nucleoside that features a propyne group at the 5-position of the cytidine base and a methoxy group at the 2'-position of the ribose sugar. This compound is characterized by its unique structural modifications, which can influence its biological activity and stability compared to unmodified nucleosides. The presence of the propyne group may enhance its reactivity and potential for incorporation into nucleic acid sequences, while the 2'-O-methyl modification is known to confer resistance to nucleases, thereby increasing the compound's stability in biological systems. Such modifications are often explored in the context of therapeutic applications, particularly in the development of antiviral agents or as components of RNA-based therapeutics. The compound's properties, including solubility, melting point, and reactivity, are influenced by these structural features, making it a subject of interest in medicinal chemistry and molecular biology research.

5-(1-PROPYNYL)-2'-O-METHYLCYTIDINE

179817-96-0: 5-(1-Propynyl)-2'-O-methylcytidine is a modified nucleoside that features a propyne group at the 5-position of the cytidine base and a methoxy group at the 2'-position of the ribose sugar. This compound is characterized by its unique structural modifications, which can influence its biological activity and stability compared to unmodified nucleosides. The presence of the propyne group may enhance its reactivity and potential for incorporation into nucleic acid sequences, while the 2'-O-methyl modification is known to confer resistance to nucleases, thereby increasing the compound's stability in biological systems. Such modifications are often explored in the context of therapeutic applications, particularly in the development of antiviral agents or as components of RNA-based therapeutics. The compound's properties, including solubility, melting point, and reactivity, are influenced by these structural features, making it a subject of interest in medicinal chemistry and molecular biology research.

Cytidine, 2'-O-methyl-5-(1-propynyl)- (9CI)

<p>2'-O-Methyl-5-propynylcytidine is an antiviral drug that inhibits the replication of retroviruses by competitive inhibition of the viral RNA polymerase. It has been shown to be effective against HIV, HSV and CMV. This drug also has shown anticancer activity in vitro and in vivo. 2'-O-Methyl-5-propynylcytidine has a novel mechanism of action and is used as a building block for oligonucleotide synthesis because it is resistant to degradation by nucleases.</p>

CAS 179817-96-0

5-(1-PROPYNYL)-2'-O-METHYLCYTIDINE

Cytidine, 2'-O-methyl-5-(1-propynyl)- (9CI)

Ref: IN-DA0027A9

2'-O-Methyl-5-propynylcytidine

Ref: 3D-NM06210