CAS 18000-24-3

7-chlorokynurenic acid

Description:

7-Chlorokynurenic acid is a chemical compound that serves as a selective antagonist of the NMDA (N-methyl-D-aspartate) receptor, which is involved in synaptic plasticity and memory function. It is a derivative of kynurenic acid, characterized by the presence of a chlorine atom at the 7-position of the kynurenine backbone. This modification enhances its pharmacological properties, making it a subject of interest in neuroscience research, particularly in the context of neurodegenerative diseases and psychiatric disorders. The compound is typically studied for its potential neuroprotective effects and its role in modulating glutamatergic signaling. In terms of physical properties, 7-chlorokynurenic acid is generally soluble in water and organic solvents, which facilitates its use in various experimental settings. Its molecular structure includes functional groups that contribute to its biological activity, and it is often synthesized in laboratory settings for research purposes. As with many chemical substances, safety and handling precautions are essential when working with 7-chlorokynurenic acid due to its biological activity.

Formula: C₁₀H₇Cl₂NO₃

InChI: InChI=1/C10H6ClNO3/c11-5-1-2-6-7(3-5)12-8(10(14)15)4-9(6)13/h1-4H,(H,12,13)(H,14,15)

InChI key: InChIKey=UAWVRVFHMOSAPU-UHFFFAOYSA-N

SMILES: OC=1C2=C(N=C(C(O)=O)C1)C=C(Cl)C=C2

Synonyms:

• 2-Quinolinecarboxylic acid, 7-chloro-4-hydroxy-
• 7-Chloro-4-Oxo-1,4-Dihydroquinoline-2-Carboxylic Acid
• 7-Chloro-4-hydroxy-2-quinolinecarboxylic acid
• 7-Chloro-4-hydroxyquinaldic acid
• 7-Chloro-4-hydroxyquinoline-2-carboxylic acid
• 7-Chloro-kynurenic acid
• 7-Chloroquinurenic acid
• Kynurenic acid, 7-chloro-
• Nsc 149792
• Quinaldic acid, 7-chloro-4-hydroxy-
• 7-Chlorokynurenic acid
• 7-CL-KYNA
• 7-CKA
• 7-chloro-4-oxo-1H-quinoline-2-carboxylic acid
• 7-Chlorokynurenic acid (7-CKA)
• 7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL
• 7-Chloro-4-hydroxyquinoline-2-carboxylic acid, 7-Cl-KYNA
• 7-chloro-4-keto-1H-quinoline-2-carboxylic acid
• 7-Chloro-4-hydroxyquinoline-2-carboxylic acid hydrochloride

2-Quinolinecarboxylic acid, 7-chloro-4-hydroxy-

CAS: 18000-24-3

Formula: C₁₀H₆ClNO₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 223.6125

Ref: IN-DA0021LB

7-Chlorokynurenic acid

CAS: 18000-24-3

7-Chlorokynurenic acid

Purity: ≥98%

Molecular weight: 223.61g/mol

Ref: 54-BUP10830

7-Chloro-4-hydroxy-quinoline-2-carboxylic acid

CAS: 18000-24-3

Formula: C₁₀H₆ClNO₃

Purity: 95%

Color and Shape: Solid

Molecular weight: 223.61

Ref: 10-F021697

7-Chlorokynurenic acid

CAS: 18000-24-3

7-Chlorokynurenic acid: selective NMDA receptor antagonist, IC50 0.56 μM, inhibits glutamate reuptake (Ki 0.59 μM), antinociceptive after neuraxial delivery.

Formula: C₁₀H₆ClNO₃

Purity: 98.83%

Color and Shape: White To Yellowish Powder

Molecular weight: 223.61

Ref: TM-T10191L

7-Chlorokynurenic acid

Controlled Product

CAS: 18000-24-3

Applications 7-Chlorokynurenic acid is an NMDA receptor antagonist and inhibitor of EAAT.

Formula: C₁₀H₆ClNO₃

Color and Shape: Neat

Molecular weight: 223.61

Ref: TR-C366958

7-Chlorokynurenic acid, 98+%

CAS: 18000-24-3

NMDA receptor antagonist at the glycine site This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Formula: C₁₀H₆ClNO₃

Purity: 98+%

Molecular weight: 223.62

Ref: 02-J61359