CAS 1800070-77-2

Borussertib

CAS: 1800070-77-2

Borussertib is a covalent-allosteric and first-in-class inhibitor of protein kinase Akt(IC50 of 0.8 nM and a Ki of 2.2 nM for Aktwt)

Formula: C₃₆H₃₂N₆O₃

Purity: 99.00%

Color and Shape: Solid

Molecular weight: 596.68

Ref: TM-T8427

Borussertib

Controlled Product

CAS: 1800070-77-2

Borussertib is a molecule that inhibits the transcriptional regulator aurora kinase A. It has been shown to be an effective anticancer drug in animal models and in human cancer cells in vitro. Borussertib inhibits cell growth by binding to the tumor suppressor protein p53, which prevents it from initiating apoptosis. Borussertib also causes cell lysis by inhibiting the production of RNA and proteins, leading to cell death. Borussertib has been shown to inhibit metastatic colorectal cancer, cervical cancer, and cancer cell viability in vitro. The mechanism of action may be due to inhibition of aurora kinase A-mediated phosphorylation of p53 or inhibition of aurora kinase A-mediated phosphorylation of retinoblastoma protein (pRb).

Formula: C₃₆H₃₂N₆O₃

Purity: Min. 95%

Molecular weight: 596.7 g/mol

Ref: 3D-AXC07077