CAS 18005-40-8

O-Ethyl methylphosphonothioate

Description:

O-Ethyl methylphosphonothioate, with the CAS number 18005-40-8, is an organophosphorus compound characterized by its phosphonate structure, which includes a phosphorus atom bonded to an ethyl group, a methyl group, and a thioate (sulfur-containing) moiety. This compound is typically a colorless to pale yellow liquid with a faint odor. It is known for its use in chemical synthesis and as a potential chemical warfare agent due to its neurotoxic properties, similar to other organophosphates. The compound acts as an acetylcholinesterase inhibitor, leading to the accumulation of acetylcholine in the synaptic cleft, which can disrupt normal nerve function. O-Ethyl methylphosphonothioate is soluble in organic solvents but has limited solubility in water. Due to its toxicity and potential environmental impact, handling and disposal of this substance require strict safety measures and regulatory compliance. Its characteristics make it a subject of interest in both chemical research and toxicology studies.

Formula: C₃H₉O₂PS

InChI: InChI=1S/C3H9O2PS/c1-3-5-6(2,4)7/h3H2,1-2H3,(H,4,7)

InChI key: InChIKey=XXNRHOAJIUSMOQ-UHFFFAOYSA-N

SMILES: O(P(C)(=O)S)CC

Synonyms:

• Empsh
• Empta
• O-Ethyl methylthiophosphonate
• O-ethyl hydrogen methylphosphonothioate
• Phosphonothioic acid, P-methyl-, O-ethyl ester
• Phosphonothioic acid, methyl-, O-ethyl ester
• O-Ethyl methylphosphonothioate

O-Ethyl Methylphosphonothioate

Controlled Product

CAS: 18005-40-8

Applications O-Ethyl Methylphosphonothioate is an intermediate in synthesizing O,S-Diethyl Methylphosphonothioate (D444460), an inhibitor of cholinesterase.
References Berman, H., et al.: J. Biol. Chem., 264, 3951 (1989); Millard, C., et al.: Biochemistry, 37, 237 (1998); Koellner, G., et al.: J. Mol. Biol., 296, 713 (2000)

Formula: C₃H₉O₂PS

Color and Shape: Neat

Molecular weight: 140.14

Ref: TR-E923735

Phosphonothioic acid, P-methyl-, O-ethyl ester

CAS: 18005-40-8

Formula: C₃H₉O₂PS

Color and Shape: Liquid

Molecular weight: 140.1411

Ref: IN-DA0021O6