(4E)-TCO-PEG3-amine, identified by its CAS number 1800507-93-0, is a chemical compound characterized by its unique structure that includes a trans-cyclooctene (TCO) moiety linked to a polyethylene glycol (PEG) chain and an amine functional group. The presence of the TCO structure allows for bioorthogonal reactions, particularly with azides, making it valuable in various applications such as bioconjugation and drug delivery. The PEG component enhances the solubility and biocompatibility of the compound, which is crucial for its use in biological systems. The amine group provides a reactive site for further chemical modifications or conjugation to other biomolecules. Overall, (4E)-TCO-PEG3-amine is notable for its utility in chemical biology, particularly in the development of targeted therapies and imaging agents, owing to its favorable properties that facilitate selective and efficient reactions in complex biological environments.

TCO-PEG3-amine is a click chemistry building block containing a TCO moiety and a free amine. Amine is very reactive with active NHS ester or with carboxylic acid in the presence of of activators suh as EDC. TCO moiety is very reactive with tetrazine ( 3rd generation click chemistry).

(4E)-TCO-PEG3-amine

1800507-93-0: (4E)-TCO-PEG3-amine, identified by its CAS number 1800507-93-0, is a chemical compound characterized by its unique structure that includes a trans-cyclooctene (TCO) moiety linked to a polyethylene glycol (PEG) chain and an amine functional group. The presence of the TCO structure allows for bioorthogonal reactions, particularly with azides, making it valuable in various applications such as bioconjugation and drug delivery. The PEG component enhances the solubility and biocompatibility of the compound, which is crucial for its use in biological systems. The amine group provides a reactive site for further chemical modifications or conjugation to other biomolecules. Overall, (4E)-TCO-PEG3-amine is notable for its utility in chemical biology, particularly in the development of targeted therapies and imaging agents, owing to its favorable properties that facilitate selective and efficient reactions in complex biological environments.

TCO-PEG3-amine equatorial isomer

TCO-PEG3-amine axial isomer

TCO-PEG3-amine is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules.

CAS 1800507-93-0

(4E)-TCO-PEG3-amine

TCO-PEG3-amine equatorial isomer

Ref: 3B-T4234

TCO-PEG3-amine axial isomer

Ref: 3B-T4233

TCO-PEG3-amine

Ref: TM-T18765