CAS 180064-38-4

Minodronic acid

Description:

Minodronic acid is a synthetic bisphosphonate compound primarily used in the treatment of osteoporosis and other bone-related disorders. It functions by inhibiting osteoclast-mediated bone resorption, thereby promoting bone density and strength. The chemical structure of minodronic acid features a phosphorus atom bonded to carbon and oxygen, characteristic of bisphosphonates, which contributes to its biological activity. It is typically administered orally and has a favorable pharmacokinetic profile, allowing for effective absorption and distribution in bone tissue. Minodronic acid is known for its relatively long half-life, which supports its therapeutic efficacy. Additionally, it exhibits low toxicity and a good safety profile, making it suitable for long-term use in patients at risk of fractures. As with other bisphosphonates, potential side effects may include gastrointestinal disturbances and, in rare cases, osteonecrosis of the jaw. Overall, minodronic acid represents a valuable option in the management of osteoporosis, particularly in postmenopausal women and individuals with glucocorticoid-induced bone loss.

Formula: C₉H₁₂N₂O₇P₂

InChI: InChI=1S/C9H12N2O7P2/c12-9(19(13,14)15,20(16,17)18)5-7-6-10-8-3-1-2-4-11(7)8/h1-4,6,12H,5H2,(H2,13,14,15)(H2,16,17,18)

InChI key: InChIKey=VMMKGHQPQIEGSQ-UHFFFAOYSA-N

SMILES: C(C(P(=O)(O)O)(P(=O)(O)O)O)C=1N2C(=NC1)C=CC=C2

Synonyms:

• (1-Hydroxy-2-(imidazo[1,2-a]pyridin-3-yl)ethane-1,1-diyl)diphosphonicacid
• 1-Hydroxy-2-(Imidazo[1,2-a]pyridin-3-yl)ethane-1,1-diphosphonic acid
• Bonoteo
• Bph 261
• Imidazo[1,2-a]pyridine, phosphonic acid deriv.
• Minodronic acid
• Ono 5920
• P,P′-(1-Hydroxy-2-imidazo[1,2-a]pyridin-3-ylethylidene)bis[phosphonic acid]
• Phosphonic Acid, (1-Hydroxy-2-Imidazo(1,2-A)Pyridin-3-Ylethylidene)Bis-
• Phosphonic acid, P,P′-(1-hydroxy-2-imidazo[1,2-a]pyridin-3-ylethylidene)bis-
• Recalbon
• Yh 529
• Ym 529
• [1-Hydroxy-2-(Imidazo[1,2-A]Pyridin-3-Yl)Ethane-1,1-Diyl]Bis(Phosphonic Acid)

Minodronate Monohydrate

CAS: 155648-60-5, 180064-38-4

Formula: C₉H₁₂N₂O₇P₂·H₂O

Purity: >98.0%(HPLC)

Color and Shape: White to Light yellow to Light red powder to crystal

Molecular weight: 340.17

Ref: 3B-M2360

Phosphonic acid, P,P'-(1-hydroxy-2-imidazo[1,2-a]pyridin-3-ylethylidene)bis-

CAS: 180064-38-4

Formula: C₉H₁₂N₂O₇P₂

Purity: 95%

Color and Shape: Solid

Molecular weight: 322.1483

Ref: IN-DA0021ON

Minodronic acid

CAS: 180064-38-4

Minodronic acid

Purity: ≥98%

Molecular weight: 322.15g/mol

Ref: 54-BUP11319

Minodronic Acid

CAS: 180064-38-4

Formula: C₉H₁₂N₂O₇P₂

Color and Shape: White To Off-White Solid

Molecular weight: 322.15

Ref: 4Z-M-093001

(1-Hydroxy-2-(imidazo[1,2-a]pyridin-3-yl)ethane-1,1-diyl)diphosphonic acid

CAS: 180064-38-4

Formula: C₉H₁₂N₂O₇P₂

Purity: 95%

Color and Shape: Solid

Molecular weight: 322.15

Ref: 10-F243949

Minodronic Acid

Controlled Product

CAS: 180064-38-4

Applications Minodronic acid is developed for osteoporosis treatment.
References Tanishima, S., et al.: Clin. Interv. Aging, 8, 185 (2013)

Formula: C₉H₁₂N₂O₇P₂

Color and Shape: Neat

Molecular weight: 322.15

Ref: TR-M344900

Minodronic acid

CAS: 180064-38-4

Minodronic acid (YM-529) is a P2X2/3 antagonist with anticancer properties, inhibiting cell growth and metastasis, and used in osteoporosis research.

Formula: C₉H₁₂N₂O₇P₂

Purity: 98.02%

Color and Shape: Solid

Molecular weight: 322.15

Ref: TM-T8436