CAS 180064-38-4: Minodronic acid

Description: Minodronic acid is a synthetic bisphosphonate compound primarily used in the treatment of osteoporosis and other bone-related disorders. It functions by inhibiting osteoclast-mediated bone resorption, thereby promoting bone density and strength. The chemical structure of minodronic acid features a phosphorus atom bonded to carbon and oxygen, characteristic of bisphosphonates, which contributes to its biological activity. It is typically administered orally and has a favorable pharmacokinetic profile, allowing for effective absorption and distribution in bone tissue. Minodronic acid is known for its relatively long half-life, which supports its therapeutic efficacy. Additionally, it exhibits low toxicity and a good safety profile, making it suitable for long-term use in patients at risk of fractures. As with other bisphosphonates, potential side effects may include gastrointestinal disturbances and, in rare cases, osteonecrosis of the jaw. Overall, minodronic acid represents a valuable option in the management of osteoporosis, particularly in postmenopausal women and individuals with glucocorticoid-induced bone loss.

Formula: C₉H₁₂N₂O₇P₂

InChI: InChI=1S/C9H12N2O7P2/c12-9(19(13,14)15,20(16,17)18)5-7-6-10-8-3-1-2-4-11(7)8/h1-4,6,12H,5H2,(H2,13,14,15)(H2,16,17,18)

InChI key: InChIKey=VMMKGHQPQIEGSQ-UHFFFAOYSA-N

SMILES: O=P(O)(O)C(O)(CC1=CN=C2C=CC=CN21)P(=O)(O)O

Synonyms:

• (1-Hydroxy-2-(imidazo[1,2-a]pyridin-3-yl)ethane-1,1-diyl)diphosphonicacid
• 1-Hydroxy-2-(Imidazo[1,2-a]pyridin-3-yl)ethane-1,1-diphosphonic acid
• Bonoteo
• Bph 261
• Imidazo[1,2-a]pyridine, phosphonic acid deriv.
• Minodronic acid
• Ono 5920
• P,P′-(1-Hydroxy-2-imidazo[1,2-a]pyridin-3-ylethylidene)bis[phosphonic acid]
• Phosphonic Acid, (1-Hydroxy-2-Imidazo(1,2-A)Pyridin-3-Ylethylidene)Bis-
• Phosphonic acid, P,P′-(1-hydroxy-2-imidazo[1,2-a]pyridin-3-ylethylidene)bis-
• Recalbon
• Yh 529
• Ym 529
• [1-Hydroxy-2-(Imidazo[1,2-A]Pyridin-3-Yl)Ethane-1,1-Diyl]Bis(Phosphonic Acid)
• [1-Hydroxy-2-(imidazo[1,2-a]pyridin-3-yl)ethylidene]bisphosphonic acid

Minodronate Monohydrate

CAS: 155648-60-5 180064-38-4

• Formula: C₉H₁₂N₂O₇P₂·H₂O
• Purity: >98.0%(HPLC)
• Color and Shape: White to Light yellow to Light red powder to crystal
• Molecular weight: 340.17

Phosphonic acid, P,P'-(1-hydroxy-2-imidazo[1,2-a]pyridin-3-ylethylidene)bis-

CAS: 180064-38-4

• Formula: C₉H₁₂N₂O₇P₂
• Purity: 95%
• Color and Shape: Solid
• Molecular weight: 322.1483

Minodronic acid

CAS: 180064-38-4

• Purity: 98.01%
• Molecular weight: 322.15g/mol

Minodronic Acid

CAS: 180064-38-4

• Formula: C₉H₁₂N₂O₇P₂
• Color and Shape: White To Off-White Solid
• Molecular weight: 322.15

(1-Hydroxy-2-(imidazo[1,2-a]pyridin-3-yl)ethane-1,1-diyl)diphosphonic acid

CAS: 180064-38-4

• Purity: 95.0%
• Color and Shape: Solid
• Molecular weight: 322.1499938964844

Minodronic Acid

CAS: 180064-38-4

Applications Minodronic acid is developed for osteoporosis treatment. References Tanishima, S., et al.: Clin. Interv. …

• Formula: C₉H₁₂N₂O₇P₂
• Color and Shape: Neat
• Molecular weight: 322.15

Minodronic acid

CAS: 180064-38-4

Minodronic acid (YM-529) is a P2X2/3 antagonist with anticancer properties, inhibiting cell growth and metastasis, …

• Formula: C₉H₁₂N₂O₇P₂
• Purity: 98.02%
• Color and Shape: Solid
• Molecular weight: 322.15

Minodronic acid

CAS: 180064-38-4

Minodronic acid is a bisphosphonate that acts as an inhibitor of osteoclasts. It is used …

• Formula: C₉H₁₂N₂O₇P₂
• Purity: Min. 95%
• Molecular weight: 322.15 g/mol