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CAS 180200-66-2

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Gatifloxacin sesquihydrate

Description:
Gatifloxacin sesquihydrate is a synthetic fluoroquinolone antibiotic characterized by its broad-spectrum antibacterial activity. It is primarily used in the treatment of various bacterial infections, particularly those affecting the respiratory tract and urinary system. The substance is a sesquihydrate, meaning it contains one and a half molecules of water for each molecule of gatifloxacin, which can influence its solubility and stability. Gatifloxacin acts by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes critical for bacterial DNA replication and transcription. This mechanism of action makes it effective against both Gram-positive and Gram-negative bacteria. The compound typically appears as a white to off-white crystalline powder and is soluble in water, which facilitates its formulation in various pharmaceutical preparations. As with many antibiotics, it is essential to use gatifloxacin judiciously to prevent the development of antibiotic resistance. Potential side effects may include gastrointestinal disturbances, central nervous system effects, and hypersensitivity reactions, necessitating careful monitoring during treatment.
Formula:C19H24FN3O5
InChI:InChI=1/C19H22FN3O4.CH4O3S/c1-10-8-22(6-5-21-10)16-14(20)7-12-15(18(16)27-2)23(11-3-4-11)9-13(17(12)24)19(25)26;1-5(2,3)4/h7,9-11,21H,3-6,8H2,1-2H3,(H,25,26);1H3,(H,2,3,4)
InChI key:InChIKey=IJOOSVJZBQQMBV-UHFFFAOYSA-N
SMILES:O(C)C1=C2N(C=C(C(O)=O)C(=O)C2=CC(F)=C1N3CC(C)NCC3)C4CC4.O
Synonyms:
  • (±)-1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid, sesquihydrate
  • 1-Cyclopropyl-6-Fluoro-1,4-Dihydro-8-Methoxy-7-(3-Methyl-1-Piperazinyl)-4-Oxo-3-Quinolinecarboxylic Acid Monohydrate
  • 1-Cyclopropyl-6-Fluoro-8-Methoxy-7-(3-Methylpiperazin-1-Yl)-4-Oxo-1,4-Dihydroquinoline-3-Carboxylic Acid Methanesulfonate (1:1)
  • 1-Cyclopropyl-6-fluoro-8-methoxy-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid sesquihydrate
  • 3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-, hydrate (2:3)
  • Gatifloxacin Sesquihydrate
  • TEQUIN
  • 1-CYCLOPROPYL-6-FLUORO-8-METHOXY-7-(3-METHYL-PIPERAZIN-1-YL)-4-OXO-1,4-DIHYDRO-QUINOLINE-3-CARBOXYLIC ACID
  • Gatifloxacin Monohydrate
  • Gatifloxacin (300 mg)
  • See more synonyms
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