CAS 180200-66-2: Gatifloxacin sesquihydrate

Description: Gatifloxacin sesquihydrate is a synthetic fluoroquinolone antibiotic characterized by its broad-spectrum antibacterial activity. It is primarily used in the treatment of various bacterial infections, particularly those affecting the respiratory tract and urinary system. The substance is a sesquihydrate, meaning it contains one and a half molecules of water for each molecule of gatifloxacin, which can influence its solubility and stability. Gatifloxacin acts by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes critical for bacterial DNA replication and transcription. This mechanism of action makes it effective against both Gram-positive and Gram-negative bacteria. The compound typically appears as a white to off-white crystalline powder and is soluble in water, which facilitates its formulation in various pharmaceutical preparations. As with many antibiotics, it is essential to use gatifloxacin judiciously to prevent the development of antibiotic resistance. Potential side effects may include gastrointestinal disturbances, central nervous system effects, and hypersensitivity reactions, necessitating careful monitoring during treatment.

Formula: C₁₉H₂₂FN₃O₄H₂O

InChI: InChI=1S/C19H22FN3O4.H2O/c1-10-8-22(6-5-21-10)16-14(20)7-12-15(18(16)27-2)23(11-3-4-11)9-13(17(12)24)19(25)26;/h7,9-11,21H,3-6,8H2,1-2H3,(H,25,26);1H2

InChI key: InChIKey=IJOOSVJZBQQMBV-UHFFFAOYSA-N

SMILES: O=C(O)C1=CN(C2=C(OC)C(=C(F)C=C2C1=O)N3CCNC(C)C3)C4CC4.O

Synonyms:

• (±)-1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid, sesquihydrate
• 1-Cyclopropyl-6-Fluoro-1,4-Dihydro-8-Methoxy-7-(3-Methyl-1-Piperazinyl)-4-Oxo-3-Quinolinecarboxylic Acid Monohydrate
• 1-Cyclopropyl-6-Fluoro-8-Methoxy-7-(3-Methylpiperazin-1-Yl)-4-Oxo-1,4-Dihydroquinoline-3-Carboxylic Acid Methanesulfonate (1:1)
• 1-Cyclopropyl-6-fluoro-8-methoxy-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid sesquihydrate
• 3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-, hydrate (2:3)
• Gatifloxacin Sesquihydrate

Gatifloxacin sesquihydrate

CAS: 180200-66-2

A broad spectrum antibiotic This Thermo Scientific Chemicals brand product was originally part of the …

• Formula: C₁₉H₂₂FN₃O₄·5H₂O
• Color and Shape: Powder or crystals or crystalline powder, White to off-white
• Molecular weight: 402.42

3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-, hydrate (2:3)

CAS: 180200-66-2

• Formula: C₃₈H₅₀F₂N₆O₁₁
• Purity: 95%
• Color and Shape: Solid
• Molecular weight: 804.834

Gatifloxacin hydrate

CAS: 180200-66-2

• Formula: C₁₉H₂₂FN₃O₄·xH₂O
• Purity: 98.0 - 102.0 % (anhydrous basis)
• Color and Shape: Off-white to pale yellow or beige powder
• Molecular weight: 375.39 (anhydrous)

Gatifloxacin Sesquihydrate

CAS: 180200-66-2

• Formula: C₁₉H₂₂FN₃O₄H₂O
• Color and Shape: Neat
• Molecular weight: 804.834

Gatifloxacin sesquihydrate

CAS: 180200-66-2

Gatifloxacin sesquihydrate, a bacterial DNA gyrase inhibitor, is used to treat tuberculosis and pneumonia.

• Formula: C₁₉H₂₄FN₃O₅
• Color and Shape: Solid
• Molecular weight: 393.41

Gatifloxacin Sesquihydrate

CAS: 180200-66-2

• Formula: C₁₉H₂₂FN₃O₄H₂O
• Purity: >95.0%(T)(HPLC)
• Color and Shape: White to Light yellow powder to crystal
• Molecular weight: 402.42

Gatifloxacin RS

CAS: 180200-66-2

• Color and Shape: White

Gatifloxacin sesquihydrate

CAS: 180200-66-2

Gatifloxacin is an antibiotic that is active against a wide range of microorganisms, including gram-positive …

• Formula: C₁₉H₂₂FN₃O₄•(H₂O)₁
• Purity: Min. 95%
• Color and Shape: Off-White To Yellow Solid
• Molecular weight: 402.42 g/mol