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CAS 1802068-51-4

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  • UNI418
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    UNI418

    CAS:
    <p>UNI418 is a dual inhibitor targeting PIKfyve and PIP5K1C, exhibiting antiviral activity against SARS-CoV-2 (EC50=1.4 μM). It inhibits the endocytosis of the virus mediated by ACE2 by suppressing PIP5K1C (IC50=60.1 nM; Kd=61 nM). Additionally, UNI418 impedes the entry of SARS-CoV-2 into host cells by inhibiting the proteolytic activation regulated by PIKfyve (Kd=0.78 nM).</p>
    Formula:C22H16N6
    Color and Shape:Solid
    Molecular weight:364.40

    Ref: TM-T200240