Metallo-β-lactamase-IN-14 is a synthetic compound designed as an inhibitor of metallo-β-lactamases (MBLs), which are enzymes produced by certain bacteria that confer resistance to a broad range of β-lactam antibiotics. This compound is characterized by its ability to bind to the active site of MBLs, thereby preventing the hydrolysis of β-lactam antibiotics and restoring their efficacy against resistant bacterial strains. The structure of Metallo-β-lactamase-IN-14 typically includes a metal-binding moiety that interacts with the zinc ions essential for the enzymatic activity of MBLs. Its effectiveness is evaluated through various biochemical assays that measure its inhibitory potency and selectivity against different MBLs. Additionally, the compound's pharmacokinetic properties, such as solubility, stability, and bioavailability, are crucial for its potential therapeutic applications. Research into Metallo-β-lactamase-IN-14 contributes to the ongoing efforts to combat antibiotic resistance, a significant global health challenge.

Metallo-β-lactamase-IN-14

1802367-43-6: Metallo-β-lactamase-IN-14 is a synthetic compound designed as an inhibitor of metallo-β-lactamases (MBLs), which are enzymes produced by certain bacteria that confer resistance to a broad range of β-lactam antibiotics. This compound is characterized by its ability to bind to the active site of MBLs, thereby preventing the hydrolysis of β-lactam antibiotics and restoring their efficacy against resistant bacterial strains. The structure of Metallo-β-lactamase-IN-14 typically includes a metal-binding moiety that interacts with the zinc ions essential for the enzymatic activity of MBLs. Its effectiveness is evaluated through various biochemical assays that measure its inhibitory potency and selectivity against different MBLs. Additionally, the compound's pharmacokinetic properties, such as solubility, stability, and bioavailability, are crucial for its potential therapeutic applications. Research into Metallo-β-lactamase-IN-14 contributes to the ongoing efforts to combat antibiotic resistance, a significant global health challenge.

<p>Metallo-β-lactamase-IN-14 (Compound 17e) serves as an inhibitor of Metallo-β-Lactamase, displaying inhibitory activity against VIM-1 and VIM-2. This compound also exhibits antibacterial effects on Gram-negative (GN) bacteria and P. aeruginosa [1].</p>

CAS 1802367-43-6

Metallo-β-lactamase-IN-14

Metallo-β-lactamase-IN-14

Ref: TM-T86884