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CAS 180272-14-4

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Solifenacin

Description:
Solifenacin is a synthetic antimuscarinic agent primarily used in the treatment of overactive bladder and associated symptoms such as urinary urgency and frequency. It functions by selectively inhibiting the M3 muscarinic receptors in the bladder, leading to relaxation of the detrusor muscle and reduced urinary contractions. Solifenacin is characterized by its chemical formula, which includes a specific arrangement of carbon, hydrogen, nitrogen, and oxygen atoms. The substance is typically administered orally and exhibits a relatively long half-life, allowing for once-daily dosing. Its pharmacokinetic profile includes good oral bioavailability and extensive hepatic metabolism, primarily via the cytochrome P450 system. Common side effects may include dry mouth, constipation, and blurred vision, which are typical of anticholinergic medications. Solifenacin's efficacy and safety profile make it a valuable option in managing urinary incontinence, although it is contraindicated in certain conditions such as urinary retention and severe gastrointestinal obstruction. Overall, Solifenacin represents a significant advancement in the pharmacological management of bladder dysfunction.
Formula:C23H26N2O2
InChI:InChI=1/C23H26N2O2/c26-23(27-21-16-24-13-10-18(21)11-14-24)25-15-12-17-6-4-5-9-20(17)22(25)19-7-2-1-3-8-19/h1-9,18,21-22H,10-16H2/t21-,22-/m0/s1
SMILES:c1ccc(cc1)[C@H]1c2ccccc2CCN1C(=O)O[C@H]1CN2CCC1CC2
Synonyms:
  • [(8R)-1-azabicyclo[2.2.2]octan-8-yl] (1S)-1-phenyl-3,4-dihydro-1H-isoquinoline-2-carboxylate
  • Solifenacin intermediate
  • (3R)-1-azabicyclo[2.2.2]oct-3-yl (1S)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate
  • quinuclidin-3-yl 1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate
  • Solifinacine
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