CAS 180272-28-0

Solifenacin N-Oxide

Description:

Solifenacin N-Oxide is a chemical compound that serves as a metabolite of the antimuscarinic agent solifenacin, which is primarily used in the treatment of overactive bladder. It is characterized by its structural modifications that include the presence of an N-oxide functional group, which influences its pharmacological properties. The compound is typically a white to off-white solid and is soluble in organic solvents. Solifenacin N-Oxide exhibits anticholinergic activity, although its potency and efficacy may differ from the parent compound. Its mechanism of action involves the inhibition of acetylcholine at muscarinic receptors, leading to reduced bladder contractions. The compound is of interest in pharmacokinetic studies to understand the metabolism of solifenacin and its potential effects on therapeutic outcomes. Safety and toxicity profiles are essential for evaluating its use in clinical settings, and ongoing research may further elucidate its role in pharmacotherapy. As with any pharmaceutical compound, proper handling and storage conditions are crucial to maintain its stability and efficacy.

Formula: C₂₃H₂₆N₂O₃

InChI: InChI=1/C23H26N2O3/c26-23(28-21-16-25(27)14-11-18(21)12-15-25)24-13-10-17-6-4-5-9-20(17)22(24)19-7-2-1-3-8-19/h1-9,18,21-22H,10-16H2/t18?,21-,22?,25?/m0/s1

SMILES: c1ccc(cc1)C1c2ccccc2CCN1C(=O)O[C@H]1CN2(=O)CCC1CC2

Synonyms:

• (1S)-3,4-dihydro-1-phenyl-2(1H)-isoquinolinecarboxylic Acid (3R)-1-Oxido-1-azabicyclo[2.2.2]oct-3-yl Ester
• (1R,3R,4R)-3-((1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)oxy)quinuclidine 1-oxide

(R)-3-(((S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)oxy)quinuclidine 1-oxide

CAS: 180272-28-0

Formula: C₂₃H₂₆N₂O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 378.4641

Ref: IN-DA0021UE

Solifenacin EP Impurity I (Solifenacin N-Oxide)

CAS: 180272-28-0

Formula: C₂₃H₂₆N₂O₃

Color and Shape: Off-White Solid

Molecular weight: 378.47

Ref: 4Z-S-184

Solifenacin N-Oxide

CAS: 180272-28-0

Color and Shape: Neat

Ref: 86-MM1342.04

Solifenacin EP Impurity I-d5 (Solifenacin-N-Oxide-d5)

CAS: 180272-28-0

Formula: C₂₃H₂₁D₅N₂O₃

Molecular weight: 383.50

Ref: 4Z-S-1855

Solifenacin EP Impurity I

CAS: 180272-28-0

Formula: C₂₃H₂₆N₂O₃

Molecular weight: 378.47

Ref: ST-EA-CP-S9009

Solifenacin N-Oxide

Controlled Product

CAS: 180272-28-0

Stability Very Hygroscopic
Applications A metabolite of Solifenacin (S676700) .
References Hammerlein, A., et al.: Clin. Pharmacokinet., 35, 49 (1998), Schwartz, J., et al.: Clin. Pharmacol. Ther., 55, 509 (1994),Wein, A., et al.: Expert Opin. Investig. Drugs, 10, 65 (2001),

Formula: C₂₃H₂₆N₂O₃

Color and Shape: Neat

Molecular weight: 378.46

Ref: TR-S676710

Solifenacin N-oxide

CAS: 180272-28-0

Solifenacin N-oxide is an anti-cholinergic agent that has been shown to be effective in the treatment of overactive bladder. Solifenacin N-oxide is a prodrug that is hydrolyzed in vivo to solifenacin, its active form. The compound reversibly binds to muscarinic receptors and inhibits the release of acetylcholine. Solifenacin N-oxide has been shown to have low levels of impurities and is highly soluble in water. It was also found to be stable when stored at room temperature for two months. This drug has a high flow rate and moderate retention time, which makes it suitable for reversed-phase liquid chromatography (RPLC). RPLC is a chromatographic technique that separates compounds by size, hydrophobicity, or charge.

Formula: C₂₃H₂₆N₂O₃

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 378.46 g/mol

Ref: 3D-IS27854