CAS 180272-45-1

(R)-1-phenyl-1,2,3,4-tetrahydroisoquinoline

Description:

(R)-1-phenyl-1,2,3,4-tetrahydroisoquinoline is a chiral organic compound characterized by its bicyclic structure, which includes a phenyl group attached to a tetrahydroisoquinoline framework. This compound is typically a colorless to pale yellow liquid or solid, depending on its purity and form. It exhibits a basic nature due to the presence of a nitrogen atom in the isoquinoline ring, allowing it to participate in various chemical reactions, including alkylation and acylation. The stereochemistry of the (R) configuration is significant, as it can influence the compound's biological activity and interactions with receptors. This compound is of interest in medicinal chemistry, particularly for its potential applications in drug development, as isoquinoline derivatives are known for their diverse pharmacological properties. Additionally, its solubility characteristics can vary, making it important to consider in formulation and synthesis processes. Overall, (R)-1-phenyl-1,2,3,4-tetrahydroisoquinoline represents a valuable scaffold in organic synthesis and pharmaceutical research.

Isoquinoline, 1,2,3,4-tetrahydro-1-phenyl-, (1R)-

CAS: 180272-45-1

Formula: C₁₅H₁₅N

Purity: 98%

Color and Shape: Solid

Molecular weight: 209.2863

Ref: IN-DA0021VF

(R)-Solifenacin EP Impurity A

CAS: 180272-45-1

Formula: C₁₅H₁₅N

Color and Shape: White To Off-White Solid

Molecular weight: 209.29

Ref: 4Z-S-1829

(R)-1-phenyl-1,2,3,4-tetrahydroisoquinoline

CAS: 180272-45-1

(R)-1-phenyl-1,2,3,4-tetrahydroisoquinoline

Purity: 98%

Molecular weight: 209.29g/mol

Ref: 54-OR91961

(R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline

CAS: 180272-45-1

Formula: C₁₅H₁₅N

Purity: >98.0%(GC)(T)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 209.29

Ref: 3B-P2215

(1R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline

Controlled Product

CAS: 180272-45-1

Formula: C₁₅H₁₅N

Color and Shape: Neat

Molecular weight: 209.29

Ref: 86-MM1342.07

(1R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline

CAS: 180272-45-1

Purity: 95.0%

Color and Shape: Solid

Molecular weight: 209.29200744628906

Ref: 10-F233927

(R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline

Controlled Product

CAS: 180272-45-1

Applications (R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline is the counterpart to (S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline, the latter enantiomer being a key intermediate in the preparation of Solifenacin (S676700), an antimuscarinic agent. Since (R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline is produced as a by-product, it has been suggested that it should be recycled in order to obtain the S enantiomer on a larger scale. (R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline is also used as a reagent to prepare quinuclidin-3-yl 1,2,3,4-tetrahydroisoquinoline-2-carboxylate derivatives, compounds that act as muscarinic receptor antagonists.
References Bolchi, C., et al.: Org. Process Res. Dev., 17, 432 (2013); Naito, R., et al.: J. Med. Chem., 48, 6597 (2005)

Formula: C₁₅H₁₅N

Color and Shape: White To Light Brown

Molecular weight: 209.29

Ref: TR-P336925

Solifenacin R Isomer

CAS: 180272-45-1

Formula: C₁₅H₁₅N

Molecular weight: 209.3

Ref: ST-EA-CP-S9047

(R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline

CAS: 180272-45-1

(R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline is a chiral molecule with four stereocenters. It is synthesized by the reaction of sulfamic acid and cyclohexene in the presence of p-toluenesulfonic acid. The product formed is then dehydrogenated to produce (R)-1-phenyl-1,2,3,4-tetrahydroisoquinoline. This compound is soluble in organic solvents such as benzene and ethane and can be used as an acceptor for chiral stationary phases.

Formula: C₁₅H₁₅N

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 209.29 g/mol

Ref: 3D-IP46848