Methyltetrazine-PEG4-Amine is a chemical compound characterized by its unique structure, which includes a methyltetrazine moiety linked to a polyethylene glycol (PEG) chain with four ethylene glycol units, terminating in an amine group. This compound is often utilized in bioconjugation and drug delivery applications due to the hydrophilic nature of the PEG segment, which enhances solubility and biocompatibility. The tetrazine part of the molecule is known for its ability to undergo rapid and selective reactions with trans-cyclooctenes, making it valuable in click chemistry for labeling and imaging purposes. The amine group allows for further functionalization, enabling the attachment of various biomolecules or therapeutic agents. Overall, Methyltetrazine-PEG4-Amine serves as a versatile tool in chemical biology and medicinal chemistry, facilitating the development of targeted therapies and diagnostic agents. Its stability, reactivity, and ease of modification make it a significant compound in research and pharmaceutical applications.

Methyltetrazine-PEG4-amine is an aqueous soluble PEGylation reagent containing a free amine and a methyltetrazine group. Methyl group improves the stability and hydrophilic PEG spacer increases water-solubility.  Methyltetrazine enable fast click reaction with TCO (trans-cycloctene).

Methyltetrazine-PEG4-Amine

1802908-05-9: Methyltetrazine-PEG4-Amine is a chemical compound characterized by its unique structure, which includes a methyltetrazine moiety linked to a polyethylene glycol (PEG) chain with four ethylene glycol units, terminating in an amine group. This compound is often utilized in bioconjugation and drug delivery applications due to the hydrophilic nature of the PEG segment, which enhances solubility and biocompatibility. The tetrazine part of the molecule is known for its ability to undergo rapid and selective reactions with trans-cyclooctenes, making it valuable in click chemistry for labeling and imaging purposes. The amine group allows for further functionalization, enabling the attachment of various biomolecules or therapeutic agents. Overall, Methyltetrazine-PEG4-Amine serves as a versatile tool in chemical biology and medicinal chemistry, facilitating the development of targeted therapies and diagnostic agents. Its stability, reactivity, and ease of modification make it a significant compound in research and pharmaceutical applications.

<p>Methyltetrazine-PEG4-amine is a polyethylene glycol (PEG) derivative serving as a PROTAC linker for the synthesis of PROTACs[1].</p>

CAS 1802908-05-9

Methyltetrazine-PEG4-Amine

Methyltetrazine-PEG4-amine

Ref: TM-T16057