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CAS 180384-57-0

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Tezosentan

Description:
Tezosentan is a selective endothelin receptor antagonist primarily targeting the endothelin-1 (ET-1) receptor, which plays a significant role in vasoconstriction and cardiovascular regulation. It is classified as a small molecule and is often investigated for its potential therapeutic applications in conditions such as pulmonary arterial hypertension and heart failure. Tezosentan exhibits a high affinity for both endothelin A and B receptors, although it is more selective for the endothelin A receptor. The compound is typically administered in a clinical setting and has been studied for its effects on reducing blood pressure and improving hemodynamics. Its chemical structure includes a sulfonamide group, contributing to its pharmacological properties. Tezosentan's mechanism of action involves blocking the effects of endothelin-1, leading to vasodilation and improved blood flow. While it has shown promise in clinical trials, its use may be limited by side effects and the need for careful patient monitoring. Overall, Tezosentan represents a significant area of research in cardiovascular pharmacotherapy.
Formula:C27H27N9O6S
InChI:InChI=1S/C27H27N9O6S/c1-16(2)18-8-9-22(29-15-18)43(38,39)34-26-23(42-21-7-5-4-6-20(21)40-3)27(41-13-12-37)31-24(30-26)17-10-11-28-19(14-17)25-32-35-36-33-25/h4-11,14-16,37H,12-13H2,1-3H3,(H,30,31,34)(H,32,33,35,36)
InChI key:InChIKey=TUYWTLTWNJOZNY-UHFFFAOYSA-N
SMILES:O(C=1C(NS(=O)(=O)C2=CC=C(C(C)C)C=N2)=NC(=NC1OCCO)C=3C=C(N=CC3)C=4NN=NN4)C5=C(OC)C=CC=C5
Synonyms:
  • 2-Pyridinesulfonamide, N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-(2-(1H-tetrazol-5-yl)-4-pyridinyl)-4-pyrimidinyl)-5-(1-methylethyl)-
  • 2-Pyridinesulfonamide, N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-[2-(2H-tetrazol-5-yl)-4-pyridinyl]-4-pyrimidinyl]-5-(1-methylethyl)-
  • Act 050089
  • N-(6-(2-Hydroxyethoxy)-5-(2-methoxyphenoxy)-2-(2-(1H-tetrazol-5-yl)-4-pyridinyl)-4-pyrimidinyl)-5-(1-methylethyl)-2-pyridinesulfonamide
  • N-(6-(2-Hydroxyethoxy)-5-(o-methoxyphenoxy)-2-(2-(1H-tetrazol-5-yl)-4-pyridyl)-4-pyrimidinyl)-5-isopropyl-2-pyridinesulfonamide
  • N-[6-(2-Hydroxyethoxy)-5-(2-methoxyphenoxy)-2-[2-(2H-tetrazol-5-yl)-4-pyridinyl]-4-pyrimidinyl]-5-(1-methylethyl)-2-pyridinesulfonamide
  • N-[6-(2-Hydroxyethoxy)-5-(2-methoxyphenoxy)-2-[2-(2H-tetrazol-5-yl)pyridin-4yl]pyrimidin-4-yl]-5-propan-2-ylpyridine-2-sulfonamide
  • N-{6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-[2-(2H-tetrazol-5-yl)pyridin-4-yl]pyrimidin-4-yl}-5-(propan-2-yl)pyridine-2-sulfonamide
  • Ro 61-6612
  • Ro 610612
  • See more synonyms
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