CAS 1806-98-0

Estradiol 17β-glucuronide

Description:

Estradiol 17β-glucuronide is a conjugated form of estradiol, a potent estrogen steroid hormone, and is characterized by the addition of a glucuronic acid moiety at the 17β position. This modification enhances its solubility and facilitates excretion from the body. The substance is typically found in biological fluids, such as urine, where it serves as a metabolite of estradiol. Estradiol 17β-glucuronide is known for its role in the regulation of estrogen levels and is often studied in the context of hormonal therapies and endocrine function. It exhibits lower biological activity compared to its parent compound, estradiol, but is important for understanding estrogen metabolism and pharmacokinetics. The compound is also utilized in research to investigate estrogen-related pathways and the effects of hormonal changes in various physiological and pathological conditions. Its chemical structure includes a steroid nucleus with hydroxyl groups and a glucuronide linkage, contributing to its unique properties and biological significance.

Formula: C₂₄H₃₂O₈

InChI: InChI=1S/C24H32O8/c1-24-9-8-14-13-5-3-12(25)10-11(13)2-4-15(14)16(24)6-7-17(24)31-23-20(28)18(26)19(27)21(32-23)22(29)30/h3,5,10,14-21,23,25-28H,2,4,6-9H2,1H3,(H,29,30)/t14-,15-,16+,17+,18+,19+,20-,21+,23-,24+/m1/s1

InChI key: InChIKey=MTKNDAQYHASLID-QXYWQCSFSA-N

SMILES: C[C@@]12[C@]([C@]3([C@@](C=4C(CC3)=CC(O)=CC4)(CC1)[H])[H])(CC[C@@H]2O[C@@H]5O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]5O)[H]

Synonyms:

• (17b)-3-hydroxyestra-1,3,5(10)-trien-17-yl b-D-glucopyranosiduronic acid
• (17β)-3-Hydroxyestra-1,3,5(10)-trien-17-yl β-<span class="text-smallcaps">D</span>-glucopyranosiduronic acid
• E₂-17G
• Estradiol 17-glucuronide
• Estradiol 17β-(β-<span class="text-smallcaps">D</span>-glucuronide)
• Estradiol 17β-glucuronide
• Estradiol glucuronide
• Estrane, β-<span class="text-smallcaps">D</span>-glucopyranosiduronic acid deriv.
• Glucopyranosiduronic acid, 3-hydroxyestra-1,3,5(10)-trien-17β-yl, β-<span class="text-smallcaps">D</span>-
• OE₂-17-β-<span class="text-smallcaps">D</span>-glucuronide
• b-D-glucopyranosiduronic acid, (17b)-3-hydroxyestra-1,3,5(10)-trien-17-yl
• β-<span class="text-smallcaps">D</span>-Glucopyranosiduronic acid, (17β)-3-hydroxyestra-1,3,5(10)-trien-17-yl
• Glucopyranosiduronic acid, 3-hydroxyestra-1,3,5(10)-trien-17β-yl, β-D-

Estradiol 17-(β-D-Glucuronide)

CAS: 1806-98-0

Formula: C₂₄H₃₂O₈

Color and Shape: Solid

Molecular weight: 448.5061

Ref: IN-DA002261

Estradiol 17-O-β-D-glucuronide

CAS: 1806-98-0

Ref: 7W-GC7268

Estradiol 17-O-β-D-glucuronide

CAS: 1806-98-0

Estradiol 17-O-β-D-glucuronide

Color and Shape: Solid

Molecular weight: 448.51g/mol

Ref: 54-BICL2226

Estradiol 17-Glucuronide

CAS: 1806-98-0

Formula: C₂₄H₃₂O₈

Molecular weight: 448.51

Ref: 4Z-E-0996

17β-Estradiol 17β-D-Glucuronide

Controlled Product

CAS: 1806-98-0

Stability Hygroscopic
Applications A metabolite of Estradiol (E888000).
References Agasan, A., et al.: J. Immunol. Methods., 177, 251 (1994), Stone, R., et al.: Science, 265, 308 (1994), Tacey, R., et al.: J. Pharm. Biomed. Anal., 2, 1303 (1994),

Formula: C₂₄H₃₂O₈

Color and Shape: Off White Solid

Molecular weight: 448.51

Ref: TR-E888015

17β-Estradiol-d3 17β-D-Glucuronide

Controlled Product

CAS: 1806-98-0

Formula: C₂₄D₃H₂₉O₈

Color and Shape: Neat

Molecular weight: 451.525

Ref: TR-E888017

17β-Estradiol 17β-D-glucuronide

CAS: 1806-98-0

17β-Estradiol 17β-D-glucuronide is a steroid that is formed by the conjugation of estradiol with glucuronic acid. It has been shown to have transport properties and can be taken up by cells in the presence of sodium taurocholate, which is a cotransporter. 17β-Estradiol 17β-D-glucuronide has been found in various tissues, such as human liver and rat liver microsomes. This drug has also been shown to inhibit enzymes, such as cholesterol synthesis. Pravastatin is an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR), which is an enzyme involved in cholesterol synthesis.

Formula: C₂₄H₃₂O₈

Purity: Min. 95%

Molecular weight: 448.5 g/mol

Ref: 3D-BAA80698

Estradiol-17β-glucuronide

CAS: 1806-98-0

Formula: C₂₄H₃₂O₈

Molecular weight: 448.51

Ref: ST-EA-CP-E28033