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CAS 1808202-93-8

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Hydroxyzine-d8 (hydrochloride)

Description:
Hydroxyzine-d8 (hydrochloride) is a deuterated form of hydroxyzine, a first-generation antihistamine commonly used for its anxiolytic, sedative, and antiemetic properties. The "d8" designation indicates that eight hydrogen atoms in the hydroxyzine molecule have been replaced with deuterium, a stable isotope of hydrogen, which can be useful in research and analytical applications, particularly in pharmacokinetics and metabolic studies. As a hydrochloride salt, it is typically presented in a crystalline form, enhancing its solubility in water. Hydroxyzine-d8 retains the pharmacological characteristics of its non-deuterated counterpart, acting primarily as an antagonist to histamine H1 receptors, thereby alleviating allergic reactions and anxiety. Its deuterated nature may influence its metabolic pathways and half-life, making it a valuable compound for studying drug metabolism. Safety and efficacy profiles are generally similar to those of hydroxyzine, but specific studies are necessary to fully understand the implications of deuteration on its pharmacodynamics and pharmacokinetics.
Formula:C21H28Cl2N2O2
Synonyms:
  • Hydroxyzine-d8 (hydrochloride)
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