CAS 1809010-50-1

Berotralstat

Description:

Berotralstat is a small molecule drug primarily developed for the treatment of hereditary angioedema (HAE), a genetic condition characterized by recurrent episodes of severe swelling. It functions as a selective inhibitor of the plasma kallikrein enzyme, which plays a crucial role in the bradykinin pathway, leading to the symptoms associated with HAE. The chemical structure of berotralstat includes specific functional groups that contribute to its pharmacological activity and selectivity. It is typically administered orally and has been shown to reduce the frequency of angioedema attacks in patients. The substance is characterized by its moderate solubility in aqueous solutions and a favorable pharmacokinetic profile, allowing for effective systemic absorption. Safety and efficacy profiles have been evaluated in clinical trials, demonstrating its potential as a therapeutic option for individuals suffering from this debilitating condition. As with any medication, monitoring for side effects and interactions with other drugs is essential during treatment.

Formula: C₃₀H₂₆F₄N₆O

Synonyms:

• Berotralstat (BCX-7353)
• Berotralstat
• 1H-Pyrazole-5-carboxamide, 1-[3-(aminomethyl)phenyl]-N-[5-[(R)-(3-cyanophenyl)[(cyclopropylmethyl)amino]methyl]-2-fluorophenyl]-3-(trifluoromethyl)-
• Berotralstat (BCX7353, BCX-7353)
• Berotralstat Crude
• (R)-1-(3-(Aminomethyl)phenyl)-N-(5-((3-cyanophenyl)((cyclopropylmethyl)amino)methyl)-2-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

Berotralstat-d4

CAS: 1809010-50-1

Formula: C₃₀H₂₂D₄F₄N₆O

Molecular weight: 566.60

Ref: 4Z-B-209010

Berotralstat

CAS: 1809010-50-1

Berotralstat (BCX7353) is an oral, low-toxicity, specific kallikrein inhibitor for hereditary angioedema research, blocking bradykinin release.

Formula: C₃₀H₂₆F₄N₆O

Color and Shape: Solid

Molecular weight: 562.56

Ref: TM-T35869

Berotralstat

CAS: 1809010-50-1

Formula: C₃₀H₂₆F₄N₆O

Molecular weight: 562.57

Ref: 4Z-B-209001

Berotralstat

Controlled Product

CAS: 1809010-50-1

Formula: C₃₀H₂₆F₄N₆O

Color and Shape: Neat

Molecular weight: 562.561

Ref: TR-B485510

Berotralstat

CAS: 1809010-50-1

Berotralstat is an anticancer drug that inhibits the activity of kinases, which are enzymes that play a critical role in the growth and proliferation of cancer cells. It has been shown to induce apoptosis, or programmed cell death, in various types of cancer cells. Berotralstat is an analog of caffeine and has been found to inhibit the activity of oxytocin receptors, which may contribute to its anti-tumor effects. This drug has also been shown to be effective against tumors in Chinese hamsters and has been detected in urine after administration. Berotralstat is a promising candidate for the treatment of various types of cancer due to its potent inhibitory effects on protein kinases.

Formula: C₃₀H₂₆F₄N₆O

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 562.6 g/mol

Ref: 3D-JXC01050