CAS 1809249-37-3

Remdesivir

Description:

Remdesivir is an antiviral medication primarily developed for the treatment of viral infections, particularly those caused by RNA viruses such as the Ebola virus and coronaviruses, including SARS-CoV-2, the virus responsible for COVID-19. It is classified as a nucleotide analog, which means it mimics the building blocks of RNA, thereby interfering with viral replication. The chemical structure of Remdesivir includes a modified adenosine nucleotide, which allows it to be incorporated into viral RNA, leading to premature termination of RNA synthesis. Remdesivir is administered intravenously and has been shown to reduce the time to recovery in hospitalized patients with severe COVID-19. Its mechanism of action involves inhibiting the viral RNA-dependent RNA polymerase, an essential enzyme for viral replication. While it has demonstrated efficacy in clinical settings, its use may be accompanied by side effects, including liver enzyme elevations and gastrointestinal symptoms. Overall, Remdesivir represents a significant advancement in antiviral therapy, particularly in the context of emerging viral pandemics.

Formula: C₂₇H₃₅N₆O₈P

InChI: InChI=1S/C27H35N6O8P/c1-4-18(5-2)13-38-26(36)17(3)32-42(37,41-19-9-7-6-8-10-19)39-14-21-23(34)24(35)27(15-28,40-21)22-12-11-20-25(29)30-16-31-33(20)22/h6-12,16-18,21,23-24,34-35H,4-5,13-14H2,1-3H3,(H,32,37)(H2,29,30,31)/t17-,21+,23+,24+,27-,42-/m0/s1

InChI key: InChIKey=RWWYLEGWBNMMLJ-YSOARWBDSA-N

SMILES: C(#N)[C@]1(O[C@H](COP(OC2=CC=CC=C2)(N[C@H](C(OCC(CC)CC)=O)C)=O)[C@@H](O)[C@H]1O)C=3N4C(=CC3)C(N)=NC=N4

Synonyms:

• GS 5734
• Remdesiver
• 2-Ethylbutyl N-[(S)-[2-C-(4-aminopyrrolo(2,1-f)(1,2,4)triazin-7-yl)-2,5-anhydro-D-altrononitril-6-O-yl]phenoxyphosphoryl]-L-alaninate
• 2-Ethylbutyl (2S)-2-[[[[(2R,3S,4R,5R)-5-(4-aminopyrrolo(2,1-f)(1,2,4)triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl]methoxy]phenoxyphosphoryl]amino]propanoate
• L-Alanine, N-[(S)-hydroxyphenoxyphosphinyl]-, 2-ethylbutyl ester, 6-ester with 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-D-altrononitrile
• Remdesivir
• high purity Remdesivir
• GS5734
• remdesivir producing The finished product
• Remdesivir lypholized powder
• Remdesivir API
• Remdesivir*(Available for selected markets)
• Remdesivir EP/USP/BP
• Ragoli
• Remdesivir liquid

Remdesivir

CAS: 1809249-37-3

Remdesivir

Purity: ≥95%

Molecular weight: 602.58g/mol

Ref: 54-BUP15280

Remdesivir

CAS: 1809249-37-3

Formula: C₂₇H₃₅N₆O₈P

Purity: ≥ 98.0%

Color and Shape: White to off-white crystalline powder

Molecular weight: 602.56

Ref: 7W-GP1071

Remdesivir

CAS: 1809249-37-3

Formula: C₂₇H₃₅N₆O₈P

Color and Shape: White To Off-White Solid

Molecular weight: 602.58

Ref: 4Z-R-137001

Remdesivir-d4

CAS: 1809249-37-3

Formula: C₂₇H₃₁D₄N₆O₈P

Color and Shape: White To Off-White Solid

Molecular weight: 606.61

Ref: 4Z-R-137002

Remdesivir

CAS: 1809249-37-3

Color and Shape: Neat

Ref: 86-MM3891.00

Remdesivir-13C-d3-15N2

CAS: 1809249-37-3

Formula: C₂₆₁₃CH₃₂D₃N₄₁₅N₂O₈P

Molecular weight: 608.58

Ref: 4Z-R-137005

Remdesivir

CAS: 1809249-37-3

Remdesivir (GS-5734) is a nucleoside analog, a broad-spectrum antiviral compound that exerts its activity by inhibiting the RNA-dependent RNA polymerase of

Formula: C₂₇H₃₅N₆O₈P

Purity: 97.62% - 99.98%

Color and Shape: Solid

Molecular weight: 602.58

Ref: TM-T7766

Remdesivir-13C3-d4-15N

CAS: 1809249-37-3

Formula: C₂₄₁₃C₃H₃₁D₄N₅₁₅NO₈P

Molecular weight: 610.58

Ref: 4Z-R-137004

Remdesivir-d4-15N

CAS: 1809249-37-3

Formula: C₂₇H₃₁D₄N₅₁₅NO₈P

Molecular weight: 607.60

Ref: 4Z-R-137003

Remdesivir

CAS: 1809249-37-3

Remdesivir

Formula: C₂₇H₃₅N₆O₈P·CH₃SO₃H

Purity: By hplc: 99.89% (Typical Value in Batch COA)

Color and Shape: white solid

Molecular weight: 698.68162g/mol

Ref: 54-BISN0317

Remdesivir

CAS: 1809249-37-3

GS 5734, also known as remdesivir is a nucleoside prodrug with broad spectrum antiviral activity against RNA viruses. As remdesivir / GS 5734 is a prodrug, it requires to be triphosphorylated by cellular kinases in order to compete with ATP for incorporation in newly replicated viral RNA. A major benefit of remdesivir in comparison with other antiviral nucleoside analogs is its resistance to proofreading exonucleases, which occur in coronaviruses. This means remdesivir can overcome the repair mechanism and preserve its antiviral activity. Remdesivir was reported to have a therapeutic as well as prophylactic efficacy in a mouse model infected with SARS-CoV-1.

Formula: C₂₇H₃₅N₆O₈P

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 602.58 g/mol

Ref: 3D-AG170167

Remdesivir

CAS: 1809249-37-3

Formula: C₂₇H₃₅N₆O₈P

Purity: 98%(HPLC);RG

Molecular weight: 602.585

Ref: 10-F547241

Remdesivir Related Compound 6-13C,D3,15N2

Controlled Product

CAS: 1809249-37-3

Formula: CC₁₁D₃H₁₀₁₅N₂N₃O₄

Color and Shape: Neat

Molecular weight: 297.261

Ref: TR-R212722

Remdesivir Carboxylic Acid

Controlled Product

CAS: 1809249-37-3

Formula: C₂₁H₂₃N₆O₈P

Color and Shape: Neat

Molecular weight: 520.43

Ref: TR-R530520

Remdesivir 5’-Desphosphate 3’-O-[(S)phosphate]

Controlled Product

CAS: 1809249-37-3

Formula: C₂₇H₃₅N₆O₈P

Color and Shape: Neat

Molecular weight: 605.60

Ref: TR-R530500

Desalanyl Remdesivir

Controlled Product

CAS: 1809249-37-3

Formula: C₁₈H₁₈N₅O₇P

Color and Shape: Neat

Molecular weight: 449.35

Ref: TR-R530530

Desamino Remdesivir Triazinone

Controlled Product

CAS: 1809249-37-3

Formula: C₂₇H₃₄N₅O₉P

Color and Shape: Neat

Molecular weight: 603.561

Ref: TR-D023635

Bi(alanine 2-Ethylbutyl Ester)Phenyl Phosphenite

Controlled Product

CAS: 1809249-37-3

Formula: C₂₄H₄₁N₂O₆P

Color and Shape: Neat

Molecular weight: 484.57

Ref: TR-B080510

Remdesivir 5’-Desphosphate 2’-O-[(S)phosphate]

Controlled Product

CAS: 1809249-37-3

Formula: C₂₇H₃₅N₆O₈P

Color and Shape: Neat

Molecular weight: 605.60

Ref: TR-R530510