CAS 181183-52-8: Almotriptan malate
Description:Almotriptan malate is a pharmaceutical compound primarily used in the treatment of migraine headaches. It belongs to the triptan class of medications, which are specifically designed to alleviate migraine symptoms by acting as agonists at serotonin receptors, particularly the 5-HT_1B and 5-HT_1D subtypes. This action leads to vasoconstriction of cranial blood vessels and inhibition of pro-inflammatory neuropeptide release. Almotriptan is characterized by its relatively high oral bioavailability and a favorable pharmacokinetic profile, which includes a moderate half-life that allows for effective management of acute migraine attacks. The malate salt form enhances its solubility and stability, facilitating absorption in the gastrointestinal tract. Almotriptan is generally well-tolerated, though it may cause side effects such as dizziness, fatigue, or sensations of tingling. As with other triptans, it is contraindicated in patients with certain cardiovascular conditions due to the potential for vasoconstriction. Overall, Almotriptan malate represents an important option in the therapeutic arsenal for migraine management.
Formula:C17H25N3O2S·C4H6O5
InChI:InChI=1S/C17H25N3O2S.C4H6O5/c1-19(2)10-7-15-12-18-17-6-5-14(11-16(15)17)13-23(21,22)20-8-3-4-9-20;5-2(4(8)9)1-3(6)7/h5-6,11-12,18H,3-4,7-10,13H2,1-2H3;2,5H,1H2,(H,6,7)(H,8,9)
InChI key:InChIKey=QHATUKWEVNMHRY-UHFFFAOYSA-N
SMILES:O=C(O)CC(O)C(=O)O.O=S(=O)(N1CCCC1)CC=2C=CC=3NC=C(C3C2)CCN(C)C
- Synonyms:
- 1-[[3-(2-Dimethylaminoethyl)-5-Indolyl]Methanesulphonyl]Pyrrolidine Malate
- 1-[[[2-(Dimethyl-Amino)Ethyl]-1H-Indol-5-Yl]Methyl]Sulfonyl]Pyrrolidine Malate
- 2-hydroxybutanedioic acid - N,N-dimethyl-2-{5-[(pyrrolidin-1-ylsulfonyl)methyl]-1H-indol-3-yl}ethanamine (1:1)
- Almotrip forte
- Almotriptan Malate
- Almotriptan Maleate
- Almotriptanmaleate
- Axert
- Butanedioic acid, 2-hydroxy-, compd. with N,N-dimethyl-5-[(1-pyrrolidinylsulfonyl)methyl]-1H-indole-3-ethanamine (1:1)
- Butanedioic acid, hydroxy-, compd with 1-[[[3-[2-(dimethylamino)ethyl]-1h-indol-5-yl]methyl]sulfonyl]pyrrolidine
- See more synonyms
- Butanedioic acid, hydroxy-, compd. with 1-[[[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]methyl]sulfonyl]pyrrolidine (1:1)
- LAS 31416 <span class="text-smallcaps">D</smallcap>,<smallcap>L</span>-malate acid
- Las-31416 Malate
- N,N-dimethyl-2-{5-[(pyrrolidin-1-ylsulfonyl)methyl]-1H-indol-3-yl}ethanamine
- Pnu 180638
- Pnu 180638E
- Pyrrolidine, 1-[[[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]methyl]sulfonyl]-, hydroxybutanedioate (1:1)
- LAS 31416 D,L-malate acid
![Butanedioic acid, 2-hydroxy-, compd. with N,N-dimethyl-5-[(1-pyrrolidinylsulfonyl)methyl]-1H-indol…](https://static.cymitquimica.com/products/IN/thumb/DA0022QH.jpg)
