CAS 181183-52-8

Almotriptan malate

Description:

Almotriptan malate is a pharmaceutical compound primarily used in the treatment of migraine headaches. It belongs to the triptan class of medications, which are specifically designed to alleviate migraine symptoms by acting as agonists at serotonin receptors, particularly the 5-HT_1B and 5-HT_1D subtypes. This action leads to vasoconstriction of cranial blood vessels and inhibition of pro-inflammatory neuropeptide release. Almotriptan is characterized by its relatively high oral bioavailability and a favorable pharmacokinetic profile, which includes a moderate half-life that allows for effective management of acute migraine attacks. The malate salt form enhances its solubility and stability, facilitating absorption in the gastrointestinal tract. Almotriptan is generally well-tolerated, though it may cause side effects such as dizziness, fatigue, or sensations of tingling. As with other triptans, it is contraindicated in patients with certain cardiovascular conditions due to the potential for vasoconstriction. Overall, Almotriptan malate represents an important option in the therapeutic arsenal for migraine management.

Formula: C₁₇H₂₅N₃O₂S·C₄H₆O₅

InChI: InChI=1/C17H25N3O2S.C4H6O5/c1-19(2)10-7-15-12-18-17-6-5-14(11-16(15)17)13-23(21,22)20-8-3-4-9-20;5-2(4(8)9)1-3(6)7/h5-6,11-12,18H,3-4,7-10,13H2,1-2H3;2,5H,1H2,(H,6,7)(H,8,9)

InChI key: InChIKey=QHATUKWEVNMHRY-UHFFFAOYSA-N

SMILES: C(CN(C)C)C=1C=2C(NC1)=CC=C(CS(=O)(=O)N3CCCC3)C2.C(CC(O)=O)(C(O)=O)O

Synonyms:

• 1-[[3-(2-Dimethylaminoethyl)-5-Indolyl]Methanesulphonyl]Pyrrolidine Malate
• 1-[[[2-(Dimethyl-Amino)Ethyl]-1H-Indol-5-Yl]Methyl]Sulfonyl]Pyrrolidine Malate
• 2-hydroxybutanedioic acid - N,N-dimethyl-2-{5-[(pyrrolidin-1-ylsulfonyl)methyl]-1H-indol-3-yl}ethanamine (1:1)
• Almotrip forte
• Almotriptan Malate
• Almotriptan Maleate
• Almotriptanmaleate
• Axert
• Butanedioic acid, 2-hydroxy-, compd. with N,N-dimethyl-5-[(1-pyrrolidinylsulfonyl)methyl]-1H-indole-3-ethanamine (1:1)
• Butanedioic acid, hydroxy-, compd with 1-[[[3-[2-(dimethylamino)ethyl]-1h-indol-5-yl]methyl]sulfonyl]pyrrolidine
• Butanedioic acid, hydroxy-, compd. with 1-[[[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]methyl]sulfonyl]pyrrolidine (1:1)
• LAS 31416 <span class="text-smallcaps">D</smallcap>,<smallcap>L</span>-malate acid
• Las-31416 Malate
• N,N-dimethyl-2-{5-[(pyrrolidin-1-ylsulfonyl)methyl]-1H-indol-3-yl}ethanamine
• Pnu 180638
• Pnu 180638E
• Pyrrolidine, 1-[[[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]methyl]sulfonyl]-, hydroxybutanedioate (1:1)
• LAS 31416 D,L-malate acid
• hydroxy-Butanedioic acid, compd.with 1-[[[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]methyl]sulfonyl]pyrrolidine(1:1)(9CI)
• N,N-dimethyl-5-[(1-pyrrolidinylsulfonyl)methyl]-1H-indole-3-ethanamine,compd. with 2-hydroxy-butanedioic acid
• Almotriptan
• AlMotriptan Malate (Axert)
• Amotriptan malate
• 1-[[[3-[2-(dimeth
• See: A575201
• 2-Hydroxy-butanedioic acid, compd. with N,N-dimethyl-5-[(1-pyrrolidinylsulfonyl)methyl]-1H-indole-3-ethanamine (1:1)
• Almotriptan Malate (200 mg)

Almotriptan Malate

CAS: 181183-52-8

Formula: C₁₇H₂₅N₃O₂SC₄H₆O₅

Molecular weight: 335.47 : 134.09

Ref: ST-EA-CP-A53037

ALMOTRIPTAN MALATE CRS

CAS: 181183-52-8

ALMOTRIPTAN MALATE CRS

Ref: 41-Y0002144

Almotriptan Malate

CAS: 181183-52-8

Sulfonamides used as drugs

Formula: C₁₇H₂₅N₃O₂S·C₄H₆O₅

Color and Shape: White Off-White Crystalline Powder

Molecular weight: 335.16675

Ref: 45-1013512

Butanedioic acid, 2-hydroxy-, compd. with N,N-dimethyl-5-[(1-pyrrolidinylsulfonyl)methyl]-1H-indole-3-ethanamine (1:1)

CAS: 181183-52-8

Formula: C₂₁H₃₁N₃O₇S

Purity: 98%

Color and Shape: Solid

Molecular weight: 469.5517

Ref: IN-DA0022QH

Almotriptan-d6 Malate

CAS: 181183-52-8

Formula: C₁₇H₁₉D₆N₃O₂S·C₄H₆O₅

Color and Shape: White To Off-White Solid

Molecular weight: 341.50 134.09

Ref: 4Z-A-051

Almotriptan Malate

CAS: 181183-52-8

Almotriptan Malate

Purity: ≥98%

Molecular weight: 469.55g/mol

Ref: 54-BUP14171

Almotriptan Malate

CAS: 181183-52-8

Formula: C₁₇H₂₅N₃O₂S·C₄H₆O₅

Color and Shape: Pale Yellow Solid

Molecular weight: 335.47 134.09

Ref: 4Z-A-052

Almotriptan malate

CAS: 181183-52-8

Formula: C₂₁H₃₁N₃O₇S

Molecular weight: 469.55

Ref: 7W-GP9851

Almotriptan Malate

CAS: 181183-52-8

Color and Shape: Neat

Ref: 86-MM3978.00

Almotriptan Malate

CAS: 154323-57-6, 181183-52-8

Formula: C₁₇H₂₅N₃O₂S·C₄H₆O₅

Purity: >98.0%(HPLC)

Color and Shape: White to Orange to Green powder to crystal

Molecular weight: 469.55

Ref: 3B-A3111

Almotriptan Malate

CAS: 181183-52-8

Almotriptan Malate (PNU180638), a selective 5-HT1B/1D receptor agonist, is used in the therapy of Migraine attacks in adults.

Formula: C₁₇H₂₅N₃O₂S·C₄H₆O₅

Purity: 99.95%

Color and Shape: Pale Yellow Solid

Molecular weight: 469.55

Ref: TM-T2317

Almotriptan Malate

CAS: 181183-52-8

Applications Almotriptan is a serotonin 5HT1B /1D-receptor agonist used for treatment of migraine.
References Fleishaker, J.C., et al.: Clin. Pharmacol. Ther., 67, 498 (2000), Kamali, F., et al.: Curr. Opin. Cent. Peripher. Nerv. Syst. Invest. Drugs, 2, 197 (2000), Dodick, D.W., et al.: Expert Opin.Pharmacother., 4, 1157 (2003)

Formula: C₁₇H₂₅N₃O₂S·C₄H₆O₅

Color and Shape: Neat

Molecular weight: 469.55

Ref: TR-A575200

Almotriptan malate

CAS: 181183-52-8

Almotriptan malate is a serotonin 1B/1D receptor agonist that is used as an anti-migraine drug, specifically for the treatment of migraine headaches with or without aura. It has been shown to cause regression of angiogenic factors and statistically significant improvement in migraine headache frequency, severity, and duration when taken within 24 hours of onset of a migraine. Almotriptan malate can be administered by nasal spray or oral tablets. The recommended dose for adults is 25-50 mg (1-2 tablets) taken at the first sign of a headache. Almotriptan malate should not be given to people who have liver impairment or are taking sodium carbonate. Side effects may include nasal congestion, dizziness, dry mouth, nausea, vomiting, and diarrhea. Almotriptan malate should be used with caution in patients with hypertension. Almotriptan malate is contraindicated in patients who have had a stroke or transient ischemic

Formula: C₁₇H₂₅N₃O₂S•C₄H₆O₅

Purity: Min. 95%

Color and Shape: Solid

Molecular weight: 469.55 g/mol

Ref: 3D-FA33641