CAS 181695-72-7

Valdecoxib

Description:

Valdecoxib is a nonsteroidal anti-inflammatory drug (NSAID) that belongs to the class of selective COX-2 inhibitors. It was primarily used for the treatment of pain and inflammation associated with conditions such as osteoarthritis and rheumatoid arthritis. Valdecoxib works by selectively inhibiting the cyclooxygenase-2 (COX-2) enzyme, which plays a crucial role in the inflammatory process, thereby reducing the production of prostaglandins that mediate pain and inflammation. The chemical formula of valdecoxib is C16H14N2O2S, and it features a sulfonamide group, which contributes to its pharmacological activity. Valdecoxib is characterized by its relatively high lipophilicity, which influences its absorption and distribution in the body. However, its use has been associated with cardiovascular risks, leading to its withdrawal from the market in several countries. As a result, while valdecoxib demonstrated efficacy in pain management, safety concerns have limited its clinical application.

Formula: C₁₆H₁₄N₂O₃S

InChI: InChI=1S/C16H14N2O3S/c1-11-15(12-7-9-14(10-8-12)22(17,19)20)16(18-21-11)13-5-3-2-4-6-13/h2-10H,1H3,(H2,17,19,20)

InChI key: InChIKey=LNPDTQAFDNKSHK-UHFFFAOYSA-N

SMILES: CC1=C(C(=NO1)C2=CC=CC=C2)C3=CC=C(S(N)(=O)=O)C=C3

Synonyms:

• 4-(5-Methyl-3-Phenyl-1,2-Oxazol-4-Yl)Benzenesulfonamide
• 4-(5-Methyl-3-Phenyl-4-Isoxazolyl)Benzenesulfonamide
• 4-(5-Methyl-3-Phenyl-Oxazol-4-Yl)Benzenesulfonamide
• 4-(5-Methyl-3-phenylisoxazol-4-yl)benzenesulfonamide
• Akos 92130
• Benzenesulfonamide, 4-(5-methyl-3-phenyl-4-isoxazolyl)-
• Bextra
• Bextra, 4-(5-Methyl-3-phenyl-4-isoxazolyl)benzenefulfonamide
• Bextra, 4-(5-Methyl-3-phenyl-4-isoxazolyl)benzenesulfonamide
• Sc 65872
• Valdyn
• Valecoxib
• Valus
• Valdecoxib

Benzenesulfonamide, 4-​(5-​methyl-​3-​phenyl-​4-​isoxazolyl)​-

CAS: 181695-72-7

Formula: C₁₆H₁₄N₂O₃S

Purity: 98%

Color and Shape: Solid

Molecular weight: 314.3590

Ref: IN-DA00231D

Valdecoxib

CAS: 181695-72-7

Valdecoxib (SC 65872), an NSAID, treats osteoarthritis, rheumatoid arthritis, and menstrual pain. Not for NSAID allergies.

Formula: C₁₆H₁₄N₂O₃S

Purity: 97.66% - 99.37%

Color and Shape: White Crystalline Powder

Molecular weight: 314.36

Ref: TM-T0219

Valdecoxib

CAS: 181695-72-7

Valdecoxib

Purity: ≥95%

Molecular weight: 314.36g/mol

Ref: 54-BUP17103

Valdecoxib

CAS: 181695-72-7

Formula: C₁₆H₁₄N₂O₃S

Purity: ≥ 98.0% (dried basis)

Color and Shape: White to off-white powder

Molecular weight: 314.36

Ref: 7W-GP8320

Valdecoxib

CAS: 181695-72-7

Valdecoxib

Purity: 98%

Molecular weight: 314.36g/mol

Ref: 54-OR1030251

Valdecoxib

CAS: 181695-72-7

Formula: C₁₆H₁₄N₂O₃S

Color and Shape: White To Off-White Solid

Molecular weight: 314.36

Ref: 4Z-V-0918

Valdecoxib

CAS: 181695-72-7

Formula: C₁₆H₁₄N₂O₃S

Purity: >98.0%(HPLC)(N)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 314.36

Ref: 3B-V0133

Valdecoxib

Controlled Product

CAS: 181695-72-7

Formula: C₁₆H₁₄N₂O₃S

Color and Shape: Yellow Powder

Molecular weight: 314.36

Ref: 86-MM0937.00

Valdecoxib

CAS: 181695-72-7

Formula: C₁₆H₁₄N₂O₃S

Color and Shape: Neat

Molecular weight: 314.36

Ref: 04-C17898100

Valdecoxib

Controlled Product

CAS: 181695-72-7

Formula: C₁₆H₁₄N₂O₃S

Color and Shape: Neat

Molecular weight: 314.36

Ref: TR-V090000

4-(5-Methyl-3-phenylisoxazol-4-yl)benzenesulfonamide

CAS: 181695-72-7

Purity: 95.0%

Color and Shape: Solid

Molecular weight: 314.3599853515625

Ref: 10-F320060

Valdecoxib

Controlled Product

CAS: 181695-72-7

COX-2 inhibitor; anti-inflammatory

Formula: C₁₆H₁₄N₂O₃S

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 314.36 g/mol

Ref: 3D-FV28650