CAS 1816990-29-0

K-Opioid receptor agonist-1

Formula: C₂₂H₂₉Cl₂N₃O₃

Synonyms:

• K-Opioid receptor agonist-1

K-Opioid receptor agonist-1

CAS: 1816990-29-0

K-Opioid receptor agonist-1 (Compound 5a) acts as an agonist for the κ-Opioid receptor, exhibiting a K_i of 0.25 nM and an EC_50 of 2 nM. This compound is capable of crossing the blood-brain barrier (BBB), evidenced by brain/plasma ratios ranging from 0.50 to 0.65. Additionally, K-Opioid receptor agonist-1 demonstrates anti-inflammatory effects in dermatitis models induced by either Arachidonic acid or oxazolidinone.

Formula: C₂₂H₂₉Cl₂N₃O₃

Molecular weight: 454.39

Ref: TM-T88205