CAS 18172-50-4

1-Demethylvincaleukoblastine

Description:

1-Demethylvincaleukoblastine, also known as vincristine, is a natural alkaloid derived from the periwinkle plant, Catharanthus roseus. It is primarily used in chemotherapy for the treatment of various cancers, including leukemia and lymphoma. The compound functions as a mitotic inhibitor, disrupting the formation of the mitotic spindle during cell division, which ultimately leads to cell death. Its mechanism of action involves binding to tubulin, preventing the polymerization of microtubules, and thereby inhibiting mitosis. 1-Demethylvincaleukoblastine is characterized by its complex structure, which includes a tetracyclic core and a unique indole moiety. The substance is typically administered intravenously due to its poor oral bioavailability. Side effects can include neurotoxicity, constipation, and myelosuppression, necessitating careful monitoring during treatment. As a potent chemotherapeutic agent, it plays a crucial role in combination therapy regimens, enhancing the efficacy of other anticancer drugs. Its use is regulated, and it is classified as a prescription medication due to its potential toxicity and the need for professional oversight in its administration.

Formula: C₄₅H₅₆N₄O₉

InChI: InChI=1S/C45H56N4O9/c1-7-41(53)22-27-23-44(39(51)56-5,35-29(14-18-48(24-27)25-41)28-12-9-10-13-32(28)46-35)31-20-30-33(21-34(31)55-4)47-36-43(30)16-19-49-17-11-15-42(8-2,37(43)49)38(58-26(3)50)45(36,54)40(52)57-6/h9-13,15,20-21,27,36-38,46-47,53-54H,7-8,14,16-19,22-25H2,1-6H3/t27-,36+,37-,38+,41-,42+,43-,44-,45-/m0/s1

InChI key: InChIKey=OBEIXXHHUOSBLA-UQUCNHJPSA-N

SMILES: C(C)[C@@]12[C@]3([C@@]4([C@]([C@](C(OC)=O)(O)[C@@H]1OC(C)=O)(NC=5C4=CC(=C(OC)C5)[C@]6(C(OC)=O)C7=C(C=8C(N7)=CC=CC8)CC[N@@]9C[C@](C6)(C[C@](CC)(O)C9)[H])[H])CCN3CC=C2)[H]

Synonyms:

• 1-Demethyl-vincaleukoblastine
• 1-Demethylvincaleukoblastine
• N-Deformylleurocristine
• N-Deformylvincristine
• N-Demethylvinblastine
• N-Demethylvincaleukoblastine
• Vincaleukoblastine, 1-demethyl-
• methyl 4-(acetyloxy)-15-[5-ethyl-5-hydroxy-9-(methoxycarbonyl)-1,4,5,6,7,8,9,10-octahydro-2H-3,7-methanoazacycloundecino[5,4-b]indol-9-yl]-3-hydroxy-16-methoxy-6,7-didehydroaspidospermidine-3-carboxylate

Vincaleukoblastine, 1-demethyl-

CAS: 18172-50-4

Formula: C₄₅H₅₆N₄O₉

Color and Shape: Solid

Molecular weight: 796.9475

Ref: IN-DA00232X

Vincristine EP Impurity C

CAS: 18172-50-4

Formula: C₄₅H₅₆N₄O₉

Color and Shape: White To Off-White Solid

Molecular weight: 796.96

Ref: 4Z-V-199

N-Desmethyl Vinblastine

Controlled Product

CAS: 18172-50-4

Stability Temperature Sensitive
Applications Impurity C.

Formula: C₄₅H₅₆N₄O₉

Color and Shape: Neat

Molecular weight: 796.95

Ref: TR-D296760

Vincristine EP Impurity C

CAS: 18172-50-4

Formula: C₄₅H₅₆N₄O₉

Molecular weight: 796.96

Ref: ST-EA-CP-V34002