CAS 1818234-19-3

Cyclohexanol, 4-[5-[4-[(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)methyl]phenyl]-2-[[(1S)-1-methylbutyl]amino]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-, trans-

Description:

Cyclohexanol, 4-[5-[4-[(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)methyl]phenyl]-2-[[(1S)-1-methylbutyl]amino]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-, trans- (CAS 1818234-19-3) is a complex organic compound characterized by its multi-ring structure and various functional groups. It features a cyclohexanol moiety, which contributes to its alcohol characteristics, including potential solubility in polar solvents and the ability to participate in hydrogen bonding. The presence of a hexahydro-1H-1,4-diazepine ring suggests potential biological activity, as diazepines are often associated with pharmacological properties. The compound also contains a pyrrolo[2,3-d]pyrimidine structure, which may enhance its reactivity and interactions with biological targets. The trans- configuration indicates specific stereochemistry, which can influence the compound's physical and chemical properties, including its melting point, boiling point, and reactivity. Overall, this compound's unique structure may make it of interest in medicinal chemistry and drug development, although specific biological activities would require further investigation.

Formula: C₃₀H₄₄N₆O

Synonyms:

• UNC 4203
• Cyclohexanol, 4-[5-[4-[(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)methyl]phenyl]-2-[[(1S)-1-methylbutyl]amino]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-, trans-

UNC 4203

CAS: 1818234-19-3

Potent and specific inhibitor of the tyrosine protein kinase Mer precursor (MERTK) with 38-fold selectivity over the FMS-like protein kinase FLT3. UNC 4203 inhibits MERTK with an IC50 value of 2.4 nM and shows favourable pharmacokinetic properties. In vivo experiments in mice showed that UNC 4203 dramatically decreased the phosphorylation of MERTK in bone marrow leukemia cells.

Formula: C₃₀H₄₄N₆O

Purity: Min. 95%

Color and Shape: Yellow Powder

Molecular weight: 504.71 g/mol

Ref: 3D-BU167832

UNC 4203

Controlled Product

CAS: 1818234-19-3

Formula: C₃₀H₄₄N₆O

Color and Shape: Neat

Molecular weight: 504.71

Ref: TR-U215515

UNC4203

CAS: 1818234-19-3

UNC4203 inhibits MERTK (1.2 nM), AXL (140 nM), TYRO3 (42 nM), FLT3 (90 nM); potent, selective, oral.

Formula: C₃₀H₄₄N₆O

Color and Shape: Solid

Molecular weight: 504.71

Ref: TM-T63444