CAS 1820-81-1
:5-Chlorouracil
Description:
5-Chlorouracil is a synthetic organic compound that belongs to the class of pyrimidine derivatives. It is characterized by the presence of a chlorine atom at the 5-position of the uracil structure, which is a nucleobase found in RNA. This modification enhances its biological activity, making it a useful compound in medicinal chemistry, particularly in the development of antiviral and anticancer agents. 5-Chlorouracil exhibits properties such as being a white to off-white crystalline solid, with moderate solubility in water and organic solvents. Its mechanism of action primarily involves the inhibition of thymidylate synthase, an enzyme crucial for DNA synthesis, thereby interfering with cell proliferation. The compound is also known for its potential side effects, which can include toxicity to rapidly dividing cells. Due to its pharmacological properties, 5-Chlorouracil has been studied for its therapeutic applications, although its use is often limited by its side effects and the development of resistance in target cells.
Formula:C4H3ClN2O2
InChI:InChI=1S/C4H3ClN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)
InChI key:InChIKey=ZFTBZKVVGZNMJR-UHFFFAOYSA-N
SMILES:O=C1C(Cl)=CNC(=O)N1
Synonyms:- 2,4(1H,3H)-Pyrimidinedione, 5-chloro-
- 5-Chloro-2,4(1H,3H)-pyrimidinedione
- 5-Chloro-2,4-dihydroxypyrimidine
- 5-Chloro-2,4-pyrimidinedione
- 5-Chloropyrimidine-2,4-diol
- 5-chloropyrimidine-2,4(1H,3H)-dione
- Ai3-26560
- Nsc 28172
- Uracil, 5-chloro-
- Uracil, 5-chloro- (VAN)
- 5-Chlorouracil
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Found 14 products.
5-Chlorouracil, 98%
CAS:<p>This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci</p>Formula:C4H3ClN2O2Purity:98%Color and Shape:Powder, White to pale cream to pale yellowMolecular weight:146.53Fluorouracil Related Compound E (5-Chloropyrimidine-2,4(1H,3H)-dione)
CAS:Compounds containing a pyrimidine ring, whether or not hydrogenated, or piperazine ring in the structure, nesoiFormula:C4H3ClN2O2Color and Shape:White Off-White PowderMolecular weight:145.988312,4(1H,3H)-Pyrimidinedione, 5-chloro-
CAS:Formula:C4H3ClN2O2Purity:98%Color and Shape:SolidMolecular weight:146.53185-Chlorouracil
CAS:<p>5-Chlorouracil is a chlorinated derivative of the pyrimidine nucleoside base uracil .</p>Formula:C4H3ClN2O2Color and Shape:SolidMolecular weight:146.53Fluorouracil EP Impurity E (Fluorouracil USP Related Compound E)
CAS:Formula:C4H3ClN2O2Color and Shape:White To Off-White SolidMolecular weight:146.535-Chlorouracil
CAS:Formula:C4H3ClN2O2Purity:>98.0%(T)(HPLC)Color and Shape:White to Light yellow powder to crystalMolecular weight:146.535-Chlorouracil
CAS:Controlled Product<p>Impurity Fluorouracil EP Impurity E<br>Applications Used for the experimental and clinical treatment of neoplastic and viral diseases. Fluorouracil EP Impurity E.<br>References Yu, H., et al.: J. Biol. Chem., 268, 15935 (1993), Staleva, L., et al.: Mutat. Res., 370, 81(1996), Harris, V., et al.: J. Mol. Biol., 326, 1389 (2003)<br></p>Formula:C4H3ClN2O2Color and Shape:NeatMolecular weight:146.535-Chlorouracil
CAS:Formula:C4H3ClN2O2Purity:98%Color and Shape:Solid, White powderMolecular weight:146.535-Chlorouracil
CAS:<p>5-Chlorouracil is a drug that is used to treat cancer. It has been shown to have biological properties, and its mechanism of action is not yet fully understood. 5-Chlorouracil can be synthesized in the laboratory by reacting sodium hydroxide with 5-chloro-2,4(1H,3H)-pyrimidinedione. In wastewater treatment plants, it reacts with organic matter in the water to form nontoxic products, such as carbon dioxide and urea. The reaction solution contains 5-chlorouracil, which undergoes tautomerization spontaneously or through the addition of base. This reaction is reversible, and both the erythro and threo forms are present in solution at equilibrium. The biological properties of 5-chlorouracil have been investigated using sublethal doses in experimental animals. In one study, 5-chlorouracil was found to inhibit xanthine oxidase activity in rats significantly more</p>Formula:C4H3ClN2O2Purity:Min. 95%Color and Shape:PowderMolecular weight:146.53 g/mol
