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CAS 182133-25-1

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Arzoxifene

Description:
Arzoxifene is a selective estrogen receptor modulator (SERM) that has been investigated primarily for its potential use in the treatment of breast cancer and osteoporosis. As a SERM, it exhibits tissue-selective estrogenic and anti-estrogenic properties, meaning it can mimic estrogen in some tissues while blocking its effects in others. This dual action is beneficial in managing conditions influenced by estrogen levels. Arzoxifene has shown promise in preclinical and clinical studies for its ability to reduce the risk of breast cancer and improve bone density without the adverse effects typically associated with traditional hormone replacement therapies. Its chemical structure includes a phenolic group, which is essential for its interaction with estrogen receptors. Additionally, Arzoxifene has been evaluated for its pharmacokinetic properties, including absorption, distribution, metabolism, and excretion, which are crucial for determining its efficacy and safety profile. Overall, Arzoxifene represents a significant advancement in the development of targeted therapies for estrogen-related conditions.
Formula:C28H29NO4S
InChI:InChI=1S/C28H29NO4S/c1-31-22-8-5-20(6-9-22)28-27(25-14-7-21(30)19-26(25)34-28)33-24-12-10-23(11-13-24)32-18-17-29-15-3-2-4-16-29/h5-14,19,30H,2-4,15-18H2,1H3
InChI key:InChIKey=MCGDSOGUHLTADD-UHFFFAOYSA-N
SMILES:O(C1=C(SC=2C1=CC=C(O)C2)C3=CC=C(OC)C=C3)C4=CC=C(OCCN5CCCCC5)C=C4
Synonyms:
  • 2-(4-Methoxyphenyl)-3-[4-(2-piperidin-1-ylethoxy)phenoxy]-1-benzothiophen-6-ol
  • 2-(4-Methoxyphenyl)-3-[4-[2-(1-piperidinyl)ethoxy]phenoxy]benzo[b]thiophene-6-ol
  • 2-(p-Methoxyphenyl)-3-(p-(2-piperidinoethoxy)phenoxy)benzo(b)thiophene-6-ol
  • Arzoxifene
  • Benzo[B]Thiophene-6-Ol, 2-(4-Methoxyphenyl)-3-[4-[2-(1-Piperidinyl)Ethoxy]Phenoxy]-
  • Ly 353381
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