CAS 182133-27-3

ARZOXIFENE HCL

Description:

Arzoxifene HCl is a selective estrogen receptor modulator (SERM) that has been investigated primarily for its potential use in the treatment of conditions such as osteoporosis and breast cancer. As a SERM, it exhibits tissue-selective estrogenic and anti-estrogenic properties, meaning it can mimic or block estrogen's effects in different tissues. This compound is characterized by its ability to bind to estrogen receptors, influencing gene expression and cellular activity in target tissues. Arzoxifene HCl has shown promise in preclinical and clinical studies for its efficacy in reducing bone resorption and improving bone density, while also potentially offering protective effects against certain types of breast cancer. Its pharmacokinetic profile includes oral bioavailability and a favorable half-life, allowing for convenient dosing regimens. Safety and tolerability profiles are essential considerations in its therapeutic applications, as with any medication. Overall, Arzoxifene HCl represents a significant advancement in the development of targeted therapies for hormone-related conditions.

Formula: C₂₈H₂₉NO₄S·ClH

InChI: InChI=1/C28H29NO4S.ClH/c1-31-22-8-5-20(6-9-22)28-27(25-14-7-21(30)19-26(25)34-28)33-24-12-10-23(11-13-24)32-18-17-29-15-3-2-4-16-29;/h5-14,19,30H,2-4,15-18H2,1H3;1H

InChI key: InChIKey=NHSNLUIMAQQXGR-UHFFFAOYSA-N

SMILES: O(C1=C(SC=2C1=CC=C(O)C2)C3=CC=C(OC)C=C3)C4=CC=C(OCCN5CCCCC5)C=C4.Cl

Synonyms:

• 2-(4-Methoxyphenyl)-3-(4-(2-(1-piperidinyl)ethoxy)phenoxy)benzo(b)thiophene-6-ol hydrochloride
• 2-(4-Methoxyphenyl)-3-{4-[2-(Piperidin-1-Yl)Ethoxy]Phenoxy}-1-Benzothiophene-6-Ol Hydrochloride (1:1)
• 2-(p-Methoxyphenyl)-3-(p-(2-(1-piperidinyl)ethoxy)phenoxy)benzo(b)thiophene-6-ol hydrochloride
• 2-(p-Methoxyphenyl)-3-(p-(2-piperidinoethoxy)phenoxy)benzo(b)thiophene-6-ol hydrochloride
• Arzoxifene hydrochloride
• Arzoxifene hydrochloride [USAN]
• Benzo(b)thiophene-6-ol, 2-(4-methoxyphenyl)-3-(4-(2-(1-piperidinyl)ethoxy)phenoxy)-, hydrochloride
• Benzo[b]thiophene-6-ol, 2-(4-methoxyphenyl)-3-[4-[2-(1-piperidinyl)ethoxy]phenoxy]-, hydrochloride (1:1)
• LY 353381 HCl
• Ly 353381
• Serm 3
• Unii-Fu88Pi0433
• Arzoxifene HCl

Arzoxifene hydrochloride

CAS: 182133-27-3

Arzoxifene hydrochloride is a potential anticancer agent that inhibits the activity of integrin receptors. It has been shown to inhibit the growth of estrogen receptor-positive breast cancer cells in vivo, and also reduces the incidence of mammary tumors in rats. Arzoxifene hydrochloride has been shown to inhibit the binding of integrins to their receptors, reducing cell proliferation and preventing tumor metastasis. The drug also binds to estrogen receptors, which may be its mechanism for inhibiting tumor growth. Arzoxifene hydrochloride is a polyunsaturated compound with a chemical structure similar to other drugs used for cancer treatment and autoimmune diseases. This drug has not been shown to have any significant interactions with other drugs, but it does have pharmacological effects on certain cells such as erythrocytes and lymphocytes.

Formula: C₂₈H₃₀ClNO₄S

Purity: Min. 95%

Molecular weight: 512.1 g/mol

Ref: 3D-HHA13327

Arzoxifene hydrochloride

CAS: 182133-27-3

Arzoxifene hydrochloride is a selective estrogen receptor modulator that is a potent estrogen antagonist in mammary and uterine tissue.

Formula: C₂₈H₃₀ClNO₄S

Purity: 98%

Color and Shape: Solid

Molecular weight: 512.06

Ref: TM-T10379