CAS 182167-02-8
:Acolbifene
Description:
Acolbifene is a selective estrogen receptor modulator (SERM) that has been investigated primarily for its potential use in the treatment of breast cancer and other estrogen-related conditions. It exhibits both estrogenic and anti-estrogenic properties, depending on the target tissue, which allows it to modulate estrogen receptor activity effectively. Acolbifene has been shown to bind to estrogen receptors, influencing gene expression and cellular processes associated with estrogen signaling. Its chemical structure includes a phenolic group, which is characteristic of many SERMs, contributing to its biological activity. The compound has been evaluated in clinical studies for its efficacy and safety profile, particularly in postmenopausal women. As with other SERMs, potential side effects may include hot flashes, thromboembolic events, and effects on lipid metabolism. Overall, Acolbifene represents a promising therapeutic option in the landscape of hormone-related therapies, with ongoing research aimed at fully elucidating its pharmacological profile and clinical applications.
Formula:C29H31NO4
InChI:InChI=1S/C29H31NO4/c1-20-26-14-11-24(32)19-27(26)34-29(28(20)21-5-9-23(31)10-6-21)22-7-12-25(13-8-22)33-18-17-30-15-3-2-4-16-30/h5-14,19,29,31-32H,2-4,15-18H2,1H3/t29-/m0/s1
InChI key:InChIKey=DUYNJNWVGIWJRI-LJAQVGFWSA-N
SMILES:CC1=C([C@@H](OC=2C1=CC=C(O)C2)C3=CC=C(OCCN4CCCCC4)C=C3)C5=CC=C(O)C=C5
Synonyms:- 2H-1-Benzopyran-7-ol, 3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidinyl)ethoxy]phenyl]-, (2S)-
- EM 652
- 2H-1-Benzopyran-7-ol, 3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidinyl)ethoxy]phenyl]-, (S)-
- Sch 57068
- (2S)-3-(4-Hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidinyl)ethoxy]phenyl]-2H-1-benzopyran-7-ol
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Found 2 products.
Acolbifene
CAS:<p>Acolbifene (SCH 57068) is a selective antagonist of estrogen receptors with IC50s of 2 nM and 0.4 nM for estradiol-induced transcriptional activity of ERα and</p>Formula:C29H31NO4Purity:98.17%Color and Shape:SolidMolecular weight:457.56
