CAS 1824-50-6

Benzylhydrochlorothiazide

Description:

Benzylhydrochlorothiazide, with the CAS number 1824-50-6, is a thiazide diuretic that is primarily used in the treatment of hypertension and edema. It functions by inhibiting sodium reabsorption in the distal convoluted tubule of the nephron, leading to increased excretion of sodium and water, which helps to lower blood pressure and reduce fluid retention. This compound typically appears as a white to off-white crystalline powder and is characterized by its relatively low solubility in water, which can influence its bioavailability and pharmacokinetics. The chemical structure features a thiazide ring, which is essential for its diuretic activity, along with a benzyl group that may contribute to its pharmacological properties. As with many medications, it is important to monitor for potential side effects, including electrolyte imbalances and dehydration. Benzylhydrochlorothiazide is often administered in conjunction with other antihypertensive agents to enhance therapeutic efficacy.

Formula: C₁₄H₁₄ClN₃O₄S₂

InChI: InChI=1S/C14H14ClN3O4S2/c15-10-7-11-13(8-12(10)23(16,19)20)24(21,22)18-14(17-11)6-9-4-2-1-3-5-9/h1-5,7-8,14,17-18H,6H2,(H2,16,19,20)

InChI key: InChIKey=BWSSMIJUDVUASQ-UHFFFAOYSA-N

SMILES: O=S1(=O)C=2C(NC(CC3=CC=CC=C3)N1)=CC(Cl)=C(S(N)(=O)=O)C2

Synonyms:

• 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3-benzyl-6-chloro-3,4-dihydro-, 1,1-dioxide
• 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-3-(phenylmethyl)-, 1,1-dioxide
• 3-benzyl-6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
• 4-Benzothiadiazine-7-Sulfonamide,3-Benzyl-6-Chloro-3,4-Dihydro-,1,1-2H-2
• 4-Benzothiadiazine-7-Sulfonamide,6-Chloro-3,4-Dihydro-3-(Phenylmethyl)-2H-2
• 6-Chloro-3,4-Dihydro-3-(Phenylmethyl)-2H-1,2,4-Benzothiadiazine-7-Sulfonamid
• 6-Chloro-3,4-dihydro-3-(phenylmethyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide
• Behyd
• Benclortriazide
• Benzclortriazide
• Benzylhydrochlorothiazide-D5
• NSC 263220
• Su 6227
• Su6227

Benzylhydrochlorothiazide

Controlled Product

CAS: 1824-50-6

Formula: C₁₄H₁₄ClN₃O₄S₂

Color and Shape: Neat

Molecular weight: 387.86

Ref: TR-B279020

Benzylhydrochlorothiazide

CAS: 1824-50-6

Benzylhydrochlorothiazide is a prodrug that is hydrolyzed to benazeprilat, its active form. Benazeprilat is a potent inhibitor of angiotensin-converting enzyme (ACE) and has been shown to be effective in the treatment of cardiac hypertrophy and other tissue conditions. It has also been shown to have an anti-diabetic effect, which may be due to its ability to increase glucose uptake and reduce insulin resistance. Benzylhydrochlorothiazide has been extensively studied in vitro and in vivo for its effects on skin conditions such as psoriasis and ichthyosis.

Formula: C₁₄H₁₄ClN₃O₄S₂

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 387.86 g/mol

Ref: 3D-FB18383