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CAS 1824-58-4

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Ethiazide

Description:
Ethiazide is a thiazide diuretic, primarily used in the treatment of hypertension and edema associated with various conditions. It functions by inhibiting sodium reabsorption in the distal convoluted tubule of the nephron, leading to increased excretion of sodium and water, which helps to lower blood pressure and reduce fluid retention. Ethiazide is characterized by its chemical formula, which includes a thiazide ring structure, contributing to its pharmacological activity. The substance is typically administered orally and is known for its moderate potency compared to other diuretics. Common side effects may include electrolyte imbalances, such as hypokalemia, and potential allergic reactions. Ethiazide's mechanism of action also involves the inhibition of carbonic anhydrase, which can further influence renal function. As with any medication, it is essential to monitor patients for adverse effects and interactions with other drugs. Overall, Ethiazide remains a valuable option in the management of certain cardiovascular and renal conditions.
Formula:C9H12ClN3O4S2
InChI:InChI=1S/C9H12ClN3O4S2/c1-2-9-12-6-3-5(10)7(18(11,14)15)4-8(6)19(16,17)13-9/h3-4,9,12-13H,2H2,1H3,(H2,11,14,15)
InChI key:InChIKey=VXLCNTLWWUDBSO-UHFFFAOYSA-N
SMILES:O=S1(=O)C=2C(NC(CC)N1)=CC(Cl)=C(S(N)(=O)=O)C2
Synonyms:
  • 3-Ethyl-3,4-dihydro-6-chloro-7-sulfamoyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
  • 3-Ethylhydrochlorothiazide
  • 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-ethyl-3,4-dihydro-, 1,1-dioxide
  • 6-chloro-3-ethyl-3,4-dihydro-1,2,4-benzothiadiazine-7-sulphonamide 1,1-dioxide
  • 6-chloro-3-ethyl-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
  • Ethiazide
  • 6-Chloro-3-ethyl-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
  • aethiazidum
  • Etizide
  • 6-chloro-3-ethyl-1,1-diketo-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide
  • See more synonyms
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