CAS 182431-12-5

Lomitapide

Description:

Lomitapide is a small molecule drug primarily used in the treatment of familial hypercholesterolemia, a genetic disorder characterized by high cholesterol levels. It functions as a microsomal triglyceride transfer protein (MTP) inhibitor, which plays a crucial role in the assembly and secretion of lipoproteins in the liver. By inhibiting MTP, Lomitapide reduces the production of very low-density lipoprotein (VLDL) and subsequently lowers levels of low-density lipoprotein (LDL) cholesterol in the bloodstream. The substance is typically administered orally and is known for its potential side effects, including gastrointestinal issues and liver enzyme elevations, necessitating regular monitoring of liver function during treatment. Lomitapide is classified as a prescription medication and is often used in conjunction with a low-fat diet and other lipid-lowering therapies to achieve optimal cholesterol management. Its chemical structure includes a pyridine ring and a long aliphatic chain, contributing to its pharmacological properties.

Formula: C₃₉H₃₇F₆N₃O₂

InChI: InChI=1S/C39H37F6N3O2/c40-38(41,42)25-46-36(50)37(33-13-5-3-10-30(33)31-11-4-6-14-34(31)37)21-7-8-22-48-23-19-28(20-24-48)47-35(49)32-12-2-1-9-29(32)26-15-17-27(18-16-26)39(43,44)45/h1-6,9-18,28H,7-8,19-25H2,(H,46,50)(H,47,49)

InChI key: InChIKey=MBBCVAKAJPKAKM-UHFFFAOYSA-N

SMILES: C(CCCN1CCC(NC(=O)C2=C(C=CC=C2)C3=CC=C(C(F)(F)F)C=C3)CC1)C4(C(NCC(F)(F)F)=O)C=5C(C=6C4=CC=CC6)=CC=CC5

Synonyms:

• 9H-Fluorene-9-carboxamide, N-(2,2,2-trifluoroethyl)-9-[4-[4-[[[4′-(trifluoromethyl)[1,1′-biphenyl]-2-yl]carbonyl]amino]-1-piperidinyl]butyl]-
• Aegr 733
• Bms 201038
• Bms 201038-01
• Bms 201238
• Lojuxta
• Lomitapide
• N-(2,2,2-Trifluoroethyl)-9-[4-[4-[[[4′-(trifluoromethyl)[1,1′-biphenyl]-2-yl]carbonyl]amino]-1-piperidinyl]butyl]-9H-fluorene-9-carboxamide

Lomitapide

CAS: 182431-12-5

Formula: C₃₉H₃₇F₆N₃O₂

Purity: >98.0%(HPLC)(qNMR)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 693.73

Ref: 3B-L0298

9H-Fluorene-9-carboxamide, N-(2,2,2-trifluoroethyl)-9-[4-[4-[[[4'-(trifluoromethyl)[1,1'-biphenyl]-2-yl]carbonyl]amino]-1-piperidinyl]butyl]-

CAS: 182431-12-5

Formula: C₃₉H₃₇F₆N₃O₂

Purity: %

Color and Shape: Solid

Molecular weight: 693.7204

Ref: IN-DA0023VL

Lomitapide

CAS: 182431-12-5

Formula: C₃₉H₃₇F₆N₃O₂

Color and Shape: White To Off-White Solid

Molecular weight: 693.73

Ref: 4Z-L-129001

Lomitapide

CAS: 182431-12-5

Lomitapide

Purity: 99%

Molecular weight: 693.73g/mol

Ref: 54-PC108875

Lomitapide

CAS: 182431-12-5

Lomitapide

Purity: ≥98%

Molecular weight: 693.72g/mol

Ref: 54-BUP15379

Lomitapide

CAS: 182431-12-5

Lomitapide (AEGR-733) blocks MTP, a key enzyme in dietary lipid absorption and VLDL assembly.

Formula: C₃₉H₃₇F₆N₃O₂

Purity: 98.91% - 99.40%

Color and Shape: Solid

Molecular weight: 693.72

Ref: TM-T6267

Lomitapide-d8

Controlled Product

CAS: 182431-12-5

Formula: C₃₉D₈H₂₉F₆N₃O₂

Color and Shape: Neat

Molecular weight: 701.77

Ref: TR-L469437

Lomitapide

Controlled Product

CAS: 182431-12-5

Applications Lomitapide is a drug used in the treatment of obesity and aids in lowering LDL cholesterol and overall cholesterol levels in subjects.
References Cuchel, M. et al.: Lancet., 381, 40 (2013); Stefanutti, C. et al.: Atherosclero. Suppl., 14, 19 (2013);

Formula: C₃₉H₃₇F₆N₃O₂

Color and Shape: Neat

Molecular weight: 693.7204

Ref: TR-L469435