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CAS 182496-01-1

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N-benzoyl-5'-O-DmTr-2'-O-(2-methoxyethyl)-5-methyl Cytidine

Description:
N-benzoyl-5'-O-DmTr-2'-O-(2-methoxyethyl)-5-methyl cytidine is a modified nucleoside that features several distinctive characteristics. This compound is a derivative of cytidine, which is one of the four nucleosides that make up RNA. The presence of a benzoyl group enhances its stability and solubility, while the 5'-O-DmTr (dimethoxytrityl) group serves as a protective moiety, commonly used in nucleic acid synthesis to prevent unwanted reactions at the 5' hydroxyl group. The 2'-O-(2-methoxyethyl) modification contributes to increased resistance to nucleases, thereby improving the compound's potential for therapeutic applications. Additionally, the 5-methyl substitution at the cytosine base can influence the compound's binding affinity and biological activity. Overall, this modified nucleoside is of interest in the fields of medicinal chemistry and molecular biology, particularly for its potential use in the development of oligonucleotide therapeutics and as a tool in RNA research.
Formula:C41H43N3O9
InChI:InChI=1S/C41H43N3O9/c1-27-25-44(40(47)43-37(27)42-38(46)28-11-7-5-8-12-28)39-36(51-24-23-48-2)35(45)34(53-39)26-52-41(29-13-9-6-10-14-29,30-15-19-32(49-3)20-16-30)31-17-21-33(50-4)22-18-31/h5-22,25,34-36,39,45H,23-24,26H2,1-4H3,(H,42,43,46,47)/t34-,35-,36-,39-/m1/s1
SMILES:Cc1cn([C@H]2[C@@H]([C@@H]([C@@H](COC(c3ccccc3)(c3ccc(cc3)OC)c3ccc(cc3)OC)O2)O)OCCOC)c(nc1=NC(=O)c1ccccc1)O
Synonyms:
  • N-Benzoyl-2'-O-Methoxyethyl-5-O-Dimethoxytrityl-5-Methylcytidine
  • N-Benzoyl-5'-O-(Bis(4-Methoxyphenyl)Phenylmethyl)-2'-O-(2-Methoxyethyl)-5-Methylcytidine
  • N-Benzoyl-5'-O- Dmtr-2'-O-(2- Methoxyethyl)-5- Methyl-Cytidine
  • 5'-O-DMT-N4-Benzoyl-5-Methy-2'-O-(2-methoxyethyl)cytidine
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