CAS 182507-20-6

Raloxifene 6,4Bis-b-D-glucuronide

Description:

Raloxifene 6,4-Bis-β-D-glucuronide is a glucuronide derivative of raloxifene, a selective estrogen receptor modulator (SERM) primarily used in the treatment and prevention of osteoporosis in postmenopausal women. This compound is characterized by its ability to bind to estrogen receptors, exerting estrogen-like effects on bone tissue while antagonizing estrogen effects in breast and uterine tissues. The glucuronidation process enhances the solubility and bioavailability of the parent compound, facilitating its excretion and potentially modulating its pharmacokinetic properties. Raloxifene 6,4-Bis-β-D-glucuronide is typically studied for its role in pharmacological activity, safety profile, and therapeutic efficacy. Its chemical structure includes multiple hydroxyl groups, contributing to its polar nature, and it is often analyzed using techniques such as high-performance liquid chromatography (HPLC) for quantification and characterization. Overall, this compound represents an important aspect of drug metabolism and pharmacology, particularly in the context of hormone-related therapies.

Formula: C₄₀H₄₃NO₁₆S

InChI: InChI=1/C40H43NO16S/c42-27(19-4-8-21(9-5-19)53-17-16-41-14-2-1-3-15-41)26-24-13-12-23(55-40-33(48)29(44)31(46)35(57-40)38(51)52)18-25(24)58-36(26)20-6-10-22(11-7-20)54-39-32(47)28(43)30(45)34(56-39)37(49)50/h4-13,18,28-35,39-40,43-48H,1-3,14-17H2,(H,49,50)(H,51,52)/t28-,29+,30-,31+,32-,33+,34?,35?,39+,40-/m1/s1

Synonyms:

• 2-[4-(b-D-glucopyranuronosyloxy)phenyl]-3-[4-[2-(1-piperidinyl)ethoxy]benzoyl]benzo[b]thien-6-yl b-D-Glucopyranosiduronic Aci
• 2-[4-(-D-glucopyranuronosyloxy)phenyl]-3-[4-[2-(1-piperidinyl)ethoxy]benzoyl]benzo[b]thien-6-yl -D-Glucopyranosiduronic Acid
• Raloxifene 6,4’-Bis--D-glucuronide

Raloxifene 6,4’-Bis-b-D-glucuronide

CAS: 182507-20-6

Formula: C₄₀H₄₃NO₁₆S

Color and Shape: Solid

Molecular weight: 825.8315

Ref: IN-DA0023Y7

Raloxifene 4',6-di-O-β-D-glucuronide

CAS: 182507-20-6

Raloxifene 4',6-di-O-β-D-glucuronide

Molecular weight: 825.83g/mol

Ref: 54-BICL2518

Raloxifene 6,4'-Bis-β-D-glucuronide

CAS: 182507-20-6

Raloxifene 6,4'-Bis-β-D-glucuronide is a Raloxifene metabolite. Raloxifene is a selective antagonist of estrogen receptor for the prevention of osteoporosis.

Formula: C₄₀H₄₃NO₁₆S

Purity: 98%

Color and Shape: Solid

Molecular weight: 825.83

Ref: TM-T12687

Raloxifene 6,4''-bis-b-D-glucuronide

CAS: 182507-20-6

Ref: 7W-GC0911

Raloxifene 6,4’-Bis-β-D-glucuronide

Controlled Product

CAS: 182507-20-6

Formula: C₄₀H₄₃NO₁₆S

Color and Shape: Neat

Molecular weight: 825.83

Ref: TR-R100005

Raloxifene 6,4'-bis-b-D-glucuronide

CAS: 182507-20-6

Raloxifene 6,4'-bis-b-D-glucuronide is a synthetic molecule that has been modified and fluorinated. It is a monosaccharide with a methyl group at C6. The synthesis of this compound starts with the conversion of raloxifene to the bis-b-D-glucuronide compound in which hydroxyl groups have been esterified by an acetyl group. The modification process includes the addition of a methyl group at C6, and then it is fluorinated. This product is soluble in water and methanol, but insoluble in ether. It has CAS number 182507-20-6 and molecular weight 536. Raloxifene 6,4'-bis-b-D-glucuronide can be used as an intermediate for the synthesis of oligosaccharides or polysaccharides.

Formula: C₄₀H₄₃NO₁₆S

Purity: Min. 95%

Molecular weight: 825.85 g/mol

Ref: 3D-MR09517

Raloxifene-d4 6,4’-Bis-Beta-D-glucuronide

Controlled Product

CAS: 182507-20-6

Applications A labelled metabolite of Raloxifene.
References Nakagawa, M., et al.: Antibiotics, 38, 1622 (1985), Chen, T., et al.: J. Antibiot., 46, 131 (1993), Dodge, J., et al.: Bioorg. Med. Chem. Lett., 7, 993 (1997), Marcus, R., et al.: Endocrine, 6, 207 (1997),

Formula: C₄₀H₃₉D₄NO₁₆S

Color and Shape: Neat

Molecular weight: 829.86

Ref: TR-R100007