CAS 182507-22-8
:RALOXIFENE-4-GLUCURONIDE
Description:
Raloxifene-4-glucuronide is a metabolite of raloxifene, a selective estrogen receptor modulator (SERM) primarily used in the treatment and prevention of osteoporosis in postmenopausal women. This compound is characterized by its glucuronidation, a process that enhances the solubility and excretion of drugs. Raloxifene-4-glucuronide exhibits a high affinity for estrogen receptors, though its activity may differ from that of its parent compound. It is typically found in biological fluids following the administration of raloxifene, serving as a marker for the drug's metabolic pathway. The compound is soluble in water due to its glucuronide moiety, which contributes to its pharmacokinetic properties. Its role in pharmacology includes potential implications in modulating bone density and reducing the risk of breast cancer, similar to raloxifene. Understanding the characteristics of raloxifene-4-glucuronide is essential for evaluating the efficacy and safety of raloxifene therapy, as well as for monitoring its metabolic profile in clinical settings.
Formula:C34H35NO10S
InChI:InChI=1/C34H35NO10S/c36-21-8-13-24-25(18-21)46-32(20-6-11-23(12-7-20)44-34-30(40)28(38)29(39)31(45-34)33(41)42)26(24)27(37)19-4-9-22(10-5-19)43-17-16-35-14-2-1-3-15-35/h4-13,18,28-31,34,36,38-40H,1-3,14-17H2,(H,41,42)/t28-,29-,30-,31?,34+/m1/s1
InChI key:InChIKey=VHXYPEXOSLGZKH-WKRHDJAJSA-N
SMILES:C(=O)(C1=C(SC=2C1=CC=C(O)C2)C3=CC=C(O[C@@H]4O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]4O)C=C3)C5=CC=C(OCCN6CCCCC6)C=C5
Synonyms:- (4-[6-Hydroxy-3-[4-[2-(1-piperidinyl)ethoxy-D4]benzoyl]benzo[b]thien-2-yl]phenyl-D-glucopyranosiduronic acid)
- 4-[6-Hydroxy-3-[4-[2-(1-piperidinyl)ethoxy-d4]benzoyl]benzo[b]thien-2-yl]phenyl-b-D-glucopyranosiduronic Acid
- 4-[6-Hydroxy-3-[4-[2-(1-piperidinyl)ethoxy]benzoyl]benzo[b]thien-2-yl]phenyl β-<span class="text-smallcaps">D</span>-glucopyranosiduronic acid
- 4-[6-Hydroxy-3-[4-[2-(1-piperidinyl)ethoxy]benzoyl]benzo[b]thien-2-yl]phenyl-D-glucopyranosiduronicacid
- 4-[6-Hydroxy-3-[4-[2-(1-piperidinyl)ethoxy]benzoyl]benzo[b]thien-2-yl]phenyl-b-D-glucopyranosiduronic Acid
- Raloxifene-D4-4'-Glucuronide
- β-<span class="text-smallcaps">D</span>-Glucopyranosiduronic acid, 4-[6-hydroxy-3-[4-[2-(1-piperidinyl)ethoxy]benzoyl]benzo[b]thien-2-yl]phenyl
- β-D-Glucopyranosiduronic acid, 4-[6-hydroxy-3-[4-[2-(1-piperidinyl)ethoxy]benzoyl]benzo[b]thien-2-yl]phenyl
- Raloxifene 4′-glucuronide
- Raloxifene-d4-4'-glucuronide lithiuM salt
- Raloxifene-4'-glucuronide lithiuM salt
- Raloxifene-4'-D-glucuronide lithium salt
- See more synonyms
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Found 13 products.
4-[6-Hydroxy-3-[4-[2-(1-piperidinyl)ethoxy]benzoyl]benzo[b]thien-2-yl]phenyl β-D-glucopyranosiduronic acid
CAS:Formula:C34H35NO10SColor and Shape:SolidMolecular weight:649.7074Raloxifene-4'-Glucuronide
CAS:Formula:C34H35NO10SColor and Shape:Pale Yellow SolidMolecular weight:649.71Raloxifene 4'-glucuronide
CAS:Raloxifene 4'-glucuronide is a primary metabolite of Raloxifene.Formula:C34H35NO10SPurity:98%Color and Shape:SolidMolecular weight:649.71Raloxifene-4'-Glucuronide Lithium Salt
CAS:Formula:C34H34NO10S·LiColor and Shape:Yellow SolidMolecular weight:648.70 6.94Raloxifene-d4 4'-Glucuronide
CAS:Controlled ProductFormula:C34D4H31NO10SColor and Shape:NeatMolecular weight:653.732Raloxifene 4’-Glucuronide
CAS:Controlled ProductApplications A metabolite of Raloxifene, a nonsteroidal estrogen receptor mixed agonist/antagonist.
References Dodge, J., et al.: Bioorg. Med. Chem. Lett., 7, 993 (1997), Jeong, E., et al.: Drug Metab. Dispos., 33, 785 (2005), Trontelj, J., et al.: Pharmacol. Res., 52, 334 (2005), Oswald, S., et al.: Clin. Pharmacol. Ther., 79 206 (2006),Formula:C34H35NO10SColor and Shape:NeatMolecular weight:649.71Raloxifene 4'-D-glucuronide
CAS:Raloxifene 4'-D-glucuronide is a drug that is a prodrug of raloxifene, and it can be used to treat osteoporosis. The compound is metabolized by glucuronidation in the liver, and it has been found to have bioequivalence with the parent drug. Raloxifene 4'-D-glucuronide is marketed under the trade name Evista.Formula:C34H35NO10SPurity:Min. 95%Color and Shape:PowderMolecular weight:649.71 g/molRaloxifene 4’-β-D-Glucuronide Lithium Salt
CAS:Controlled ProductStability Hygroscopic
Applications Raloxifene 4’-Glucuronide Lithium Salt is a metabolite of Raloxifene (R099995), a nonsteroidal estrogen receptor mixed agonist/antagonist.
References Dodge, J., et al.: Bioorg. Med. Chem. Lett., 7, 993 (1997); Jeong, E., et al.: Drug Metab. Dispos., 33, 785 (2005); Trontelj, J., et al.: Pharmacol. Res., 52, 334 (2005); Oswald, S., et al.: Clin. Pharmacol. Ther., 79 206 (2006)Formula:C34H34LiNO10SColor and Shape:NeatMolecular weight:655.64Raloxifene-d4 4’-β-D-Glucuronide Lithium Salt
CAS:Controlled ProductFormula:C34D4H31NO10S·LiColor and Shape:NeatMolecular weight:660.673Raloxifene-4'-D-glucuronide lithium salt
CAS:Raloxifene-4'-D-glucuronide lithium salt is a metabolite of raloxifene, an estrogen receptor modulator. It has been used in the treatment of osteoporosis and breast cancer. Raloxifene-4'-D-glucuronide lithium salt inhibits protein synthesis by inhibiting the activity of ribosomes. Raloxifene-4'-D-glucuronide lithium salt binds to microsomal preparations, which are organelles found in liver cells that synthesize proteins. This binding slows down the rate at which proteins are synthesized, leading to its anti-cancer properties.Formula:C34H34NO10S·LiPurity:Min. 95%Molecular weight:655.64 g/mol
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