CAS 1825352-65-5: Risdiplam

Description:Risdiplam is a small molecule drug primarily developed for the treatment of spinal muscular atrophy (SMA), a genetic disorder characterized by the loss of motor neurons. It functions as a survival motor neuron 2 (SMN2) splicing modifier, enhancing the production of functional SMN protein, which is crucial for motor neuron health. Risdiplam is characterized by its oral bioavailability, allowing for convenient administration compared to other therapies that require injections. The compound has a relatively low molecular weight and exhibits good solubility, which contributes to its pharmacokinetic profile. Its mechanism of action involves modulating the splicing of SMN2 pre-mRNA, thereby increasing the levels of SMN protein in the body. Risdiplam has undergone extensive clinical trials, demonstrating efficacy in improving motor function in patients with SMA. As with any medication, it is essential to monitor for potential side effects, which may include gastrointestinal disturbances and other systemic effects. Overall, Risdiplam represents a significant advancement in the therapeutic landscape for SMA.

Formula:C₂₂H₂₃N₇O

InChI:InChI=1S/C22H23N7O/c1-14-9-18(26-29-11-15(2)24-21(14)29)17-10-20(30)28-12-16(3-4-19(28)25-17)27-8-7-23-22(13-27)5-6-22/h3-4,9-12,23H,5-8,13H2,1-2H3

InChI key:InChIKey=ASKZRYGFUPSJPN-UHFFFAOYSA-N

SMILES:O=C1C=C(N=C2C=CC(=CN12)N3CCNC4(C3)CC4)C5=NN6C=C(N=C6C(=C5)C)C

Found 5 products.

Product data	Purity	Price range	Estimated delivery
Risdiplam REF: IN-DA01EO3UCAS: 1825352-65-5	99%	To inquire	Tue 25 Mar 25
Risdiplam REF: 4Z-R-144001CAS: 1825352-65-5	- - -	To inquire	Mon 24 Mar 25
Risdiplam-d4 REF: 4Z-R-144002CAS: 1825352-65-5	- - -	To inquire	Mon 24 Mar 25
Risdiplam REF: TM-T16757CAS: 1825352-65-5	99.36% - 99.43%	60.00 €~747.00 €	Tue 01 Apr 25
Risdiplam REF: 3D-BR166842CAS: 1825352-65-5	Min. 98 Area-%	207.00 €~7,477.00 €	Thu 03 Apr 25